Cat. No. 2734
Alternative Name: PNU 89843
Chemical Name: 6,7-Dimethyl-2,4-di-1-pyrrolidinyl-
Biological ActivityPositive allosteric modulator of GABAA receptors. Enhances GABA-induced Cl- currents in the α1β2γ2, α3β2γ2 and α6β2γ2 subtypes. Causes sedation in vivo following i.v. administration without losing "righting reflex". Also displays antioxidant activity.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Rohn et al (1996) Inhibition of Ca2+-pump ATPase and the Na+/K+-pump ATPase by iron-generated free radicals. Biochem.Pharmacol. 51 471. PMID: 8619892.
Bundy et al (1995) Synthesis of novel 2,4-diaminopyrrolo-[2,3-d]pyrimidines with antioxidant, neuroprotective, and antiasthma activity. J.Med.Chem. 38 4161. PMID: 7473542.
Haesook et al (1995) U-89843A is a novel allosteric modulator of γ-aminobutyric acidA receptors. J.Pharmacol.Exp.Ther. 275 1390. PMID: 8531107.
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Keywords: U 89843A, supplier, Positive, allosteric, modulators, GABAA, receptors, Receptors, U89843A, PNU89843, Tocris Bioscience, GABAA Receptor Modulator products