Cat. No. 2175
Chemical Name: (3R,11bR)-rel-1,3,4,6,7,11b-hexahyd
Biological ActivityPotent inhibitor of vesicular monoamine uptake; depletes stores of dopamine, serotonin and noradrenalin. Binds with high affinity (IC50= 3.2 nM) to vesicular monoamine transporter (VMAT) in chromaffin granule membranes and displays higher affinity for VMAT2 than VMAT1. Also reported to block dopamine receptors. Causes behavioral depression; inhibits locomotor activity and produces hypothermia upon systemic administration in rats and mice.
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Certificate of Analysis / Product Datasheet / Safety Datasheet
Peter et al (1996) Chimeric vesicular monoamine transporters identify structural domains that influence substrate affinity and sensitivity to tetrabenazine. J.Biol.Chem. 271 2979. PMID: 8621690.
Pettibone et al (1984) Tetrabenazine-induced depletion of brain monoamines: characterisation and interaction with selected antidepressants. Eur.J.Pharmacol. 102 425. PMID: 6489435.
Reches et al (1983) Tetrabenazine, an amine-depleting drug, also blocks dopamine receptors in rat brain. J.Pharmacol.Exp.Ther 225 515. PMID: 6864517.
Scherman et al (1983) Characterisation of the monoamine carrier of chromaffin granule membrane by binding of [2-3H]dihydrotetrabenazine. Proc.Natl.Acad.Sci.USA 80 584.
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Keywords: Tetrabenazine, supplier, Potent, inhibitors, inhibits, vesicular, monoamine, transport, depletes, noradrenalin, stores, dopamine, 5-HT, Noradrenalin, Transporter, NET, Adrenergic, Transporters, Monoamine, Neurotransmitter, DAT, Dopamine, Serotonin, SERT, reuptake, 5-Hydroxytryptamine, noradrenaline, Tocris Bioscience, Vesicular Monoamine Transporter Inhibitor products
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