RS 127445 hydrochloride

Cat. No. 2993

RS 127445 hydrochloride C17H16FN3.HCl [199864-86-3]

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Alternative Name: MT 500

Chemical Name: 4-(4-Fluoro-1-naphthalenyl)-6-(1-methylethyl)-2-pyrimidinamine hydrochloride

Biological Activity

High affinity 5-HT2B receptor antagonist (pKi = 9.5). Displays 1000-fold selectivity for 5-HT2B with good bioavailability.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>98 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Callebert et al (2006) Evidence for a control of plasma serotonin levels by 5-Hydroxytryptamine2B receptors in mice. J.Pharmacol.Exp.Ther. 317 724. PMID: 16461587.

Bonhaus et al (1999) RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist. Br.J.Pharmacol. 127 1075. PMID: 10455251.

If you know of a relevant reference for RS 127445 hydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for RS 127445 hydrochloride include:

Tanaka et al (2014) Neuroendocrine signaling via the serotonin transporter regulates clearance of apoptotic cells. J Biol Chem 289 10466. PMID: 24570000.

Chabbi-Achengli et al (2013) Serotonin 2B receptor (5-HT2B R) signals through prostacyclin and PPAR-β/δ in osteoblasts. PLoS One 8 e75783. PMID: 24069449.

Söhle et al (2012) Identification of new genes involved in human adipogenesis and fat storage. PLoS One 7 e31193. PMID: 22384002.

Do you know of a great paper that uses RS 127445 hydrochloride from Tocris? If so please let us know.

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