PKC 412

Cat. No. 2992

PKC 412 C35H30N4O4 [120685-11-2]

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Alternative Name: CGP 41251

Chemical Name: [9S-(9α,10β,11β,13α)]-N-(2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-1-oxo-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-11-yl)-N-methylbenzamide

Biological Activity

Broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms (α, β, γ), PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity.

Technical Data

M.Wt:
570.64
Formula:
C35H30N4O4
Solubility:
Soluble to 15 mM in DMSO
Purity:
>98 %
Storage:
Store at -20°C
CAS No:
120685-11-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Nakazono-Kusaba et al (2004) PKC412 induces apoptosis through a caspase-dependent mechanism in human keloid-derived fibroblasts. Eur.J.Pharmacol. 497 155. PMID: 15306200.

Tenzer et al (2001) The phosphatidylinositide 3'-kinase/Akt survival pathway is a target for the anticancer and radiosensitizing agent PKC412, an inhibitor of protein kinase C. Cancer Res. 61 8203. PMID: 11719451.

Fabbro et al (2000) PKC412 - a protein kinase inhibitor with a broad therapeutic potential. Anticancer Drug Des. 15 17. PMID: 10888033.

If you know of a relevant reference for PKC 412 please let us know.

Citations are publications that use Tocris products. Selected citations for PKC 412 include:

Kuan et al (2014) Ets and GATA Transcription Factors Play a Critical Role in PMA-Mediated Repression of the ckβ Promoter via the Protein Kinase C Signaling Pathway. PLoS One 9 e113485. PMID: 25490397.

Woolley et al (2012) H2O2 production downstream of FLT3 is mediated by p22phox in the endoplasmic reticulum and is required for STAT5 signalling. PLoS One 7 e34050. PMID: 22807997.

Wasag et al (2011) The kinase inhibitor TKI258 is active against the novel CUX1-FGFR1 fusion detected in a patient with T-lymphoblastic leukemia/lymphoma and t(7;8)(q22;p11). Haematologica 96 922. PMID: 21330321.

Do you know of a great paper that uses PKC 412 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: PKC 412, supplier, Broad, spectrum, protein, kinases, inhibitors, inhibits, conventional, PKC, PKC412, CGP41251, Tocris Bioscience, Protein Kinase C Inhibitor products

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