Cat. No. 2991

DPNI-caged-GABA C15H23N3O12P2 [927866-58-8]

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Chemical Name: 1-(4-Aminobutanoyl)-4-[1,3-bis(dihydroxyphosphoryloxy)propan-2-yloxy]-7-nitroindoline

Biological Activity

Nitroindoline-caged GABA (Cat.No. 0344) with similar photochemical properties to MNI-glutamate (Cat. No. 1490); for example, the same quantum yield (0.085). Highly water soluble; exhibits fast photorelease that is efficient at near-UV and 405 nm wavelengths.

Licensing Information

Sold under licence from the Medical Research Council.

Technical Data

Soluble to 2 mM in water with gentle warming
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Trigo (2010) Presynaptic miniature GABAergic currents in developing interneurons. Neuron 66 235. PMID: 20435000.

Trigo et al (2009) Laser photolysis of DPNI-GABA, a tool for investigating the properties and distribution of GABA receptors and for silencing neurons in situ. J.Neurosci.Meths. 181 159. PMID: 19422852.

Wieboldt et al (1994) Synthesis and photochemistry of photolabile derivatives of gamma-aminobutyric acid for chemical kinetic investigations of the gamma-aminobutyric acid receptor in the millisecond time region. Biochemistry 33 1526. PMID: 8312272.

If you know of a relevant reference for DPNI-caged-GABA please let us know.

Citations are publications that use Tocris products. Selected citations for DPNI-caged-GABA include:

Nunez-Parra et al (2013) Disruption of centrifugal inhibition to olfactory bulb granule cells impairs olfactory discrimination. PLoS One 110 14777. PMID: 23959889.

Do you know of a great paper that uses DPNI-caged-GABA from Tocris? If so please let us know.

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Keywords: DPNI-caged-GABA, supplier, nitroindoline, reduces, peak, GABA-evoked, responses, caged, compounds, Tocris Bioscience, Photolysis products

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