BIBR 1532

Cat. No. 2981

BIBR 1532 C21H17NO3 [321674-73-1]

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Chemical Name: 2-[[(2E)-3-(2-Naphthalenyl)-1-oxo-2-butenyl1-yl]amino]benzoic acid

Biological Activity

Selective telomerase inhibitor (IC50 values are 93, > 100000 and > 100000 nM for human telomerase, human RNA polymerase I and human RNA polymerase II + III respectively). Causes telomere shortening in exponentially growing NCI-H460 lung carcinoma cells and eventual growth arrest.

Technical Data

M.Wt:
331.36
Formula:
C21H17NO3
Solubility:
Soluble to 100 mM in DMSO and to 25 mM in ethanol
Purity:
>98 %
Storage:
Store at RT
CAS No:
321674-73-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Rankin et al (2008) Telomerase inhibitors and 'T-oligo' as caner therapeutics: contrasting molecular mechanisms of cytotoxicity. Anticancer Drugs 19 329. PMID: 18454043.

Phatak and Burger (2007) Telomerase and its potential for therapeutic intervention. Br.J.Pharmacol. 152 1003. PMID: 17603541.

Damm et al (2001) A highly selective telomerase inhibitor limiting human cell proliferation. EMBO J. 20 6958. PMID: 11742973.

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Citations are publications that use Tocris products. Selected citations for BIBR 1532 include:

Farnung et al (2012) Telomerase efficiently elongates highly transcribing telomeres in human cancer cells. PLoS One 7 e35714. PMID: 22558207.

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Keywords: BIBR 1532, supplier, Selective, telomerase, inhibitors, inhibits, BIBR1532, Tocris Bioscience, Telomerase Inhibitor products

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