SCH 39166 hydrobromide
Cat. No. 2299
Alternative Name: Ecopipam hydrobromide
Chemical Name: (6aS-trans)-11-Chloro-6,6a,7,8,9,13
Biological ActivityHigh affinity dopamine D1/D5 receptor antagonist; displays Ki values of 1.2, 2, 980, 5520, 80 and 731 nM for binding to D1, D5, D2, D4, 5-HT and α2a receptors, respectively.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Wu et al (2005) Dopamine D1/D5 receptor antagonists with improved pharmacokinetics: design, synthesis, and biological evaluation of phenol bioisosteric analogues of benzazepine D1/D5 antagonists. J.Med.Chem. 48 680. PMID: 15689153.
Terry and Katz (1994) A comparison of the effects of the D1 receptor antagonists SCH 23390 and SCH 39166 on suppression of feeding behaviour by the D1 agonist SKF38393. Psychopharmacology 113 328. PMID: 7862841.
McQuade et al (1991) In vivo binding of SCH 39166: a D-1 selective antagonist. J.Pharmacol.Exp.Ther. 257 42. PMID: 1826927.
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Citations are publications that use Tocris products. Selected citations for SCH 39166 hydrobromide include:
Zheng et al (2014) Attenuated dopaminergic tone in the paraventricular nucleus contributing to sympathoexcitation in rats with Type 2 diabetes. Nat Commun 306 R138. PMID: 24305061.
Mizuta et al (2013) The dopamine D1 receptor is expressed and facilitates relaxation in airway smooth muscle. Am J Physiol Regul Integr Comp Physiol 14 89. PMID: 24004608.
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Keywords: SCH 39166 hydrobromide, supplier, High, affinity, D1/D5, receptor, antagonists, Dopamine, Receptors, dopaminergic, SCH39166, hydrobromide, Tocris Bioscience, D1 and D5 Receptor Antagonist products
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