TCS PIM-1 1

Cat. No. 2979

TCS PIM-1 1 C18H11BrN2O2 [491871-58-0]

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Chemical Name: 3-Cyano-4-phenyl-6-(3-bromo-6-hydroxy)phenyl-2(1H)-pyridone

Biological Activity

ATP-competitive Pim-1 kinase inhibitor that displays selectivity over Pim-2 and MEK1/2 (IC50 values are 50, > 20000 and > 20000 nM for Pim-1, Pim-2 and MEK1/2 respectively).

Technical Data

M.Wt:
367.2
Formula:
C18H11BrN2O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
491871-58-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Cheney et al (2007) Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase. Bioorg.Med.Chem.Letts. 17 1679. PMID: 17251021.

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Keywords: TCS PIM-1 1, supplier, Selective, ATP-competitive, Pim-1, kinases, inhibitors, inhibits, TCSPIM11, Tocris Bioscience, Pim Kinase Inhibitor products

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