Sarcosine

Cat. No. 2975

Sarcosine C3H7NO2 [107-97-1]

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Chemical Name: N-Methylglycine

Biological Activity

Endogenous inhibitor of GlyT1 that displays antipsychotic activity. Potentiates the action of glycine on the NMDA glycine binding site.

Technical Data

M.Wt:
89.09
Formula:
C3H7NO2
Solubility:
Soluble to 100 mM in water
Storage:
Store at RT
CAS No:
107-97-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Singh and Singh (2011) Meta-analysis of the efficacy of adjunctive NMDA receptor modulators in chronic schizophrenia. CNS Drugs. 25 859. PMID: 21936588.

Tsai et al (2004) Glycine transporter I inhibitor, N-methylglycine (Sarcosine), added to antipsychotics for the treatment of schizophrenia. Biol.Psychiatry 55 452. PMID: 15023571.

If you know of a relevant reference for Sarcosine please let us know.

Citations are publications that use Tocris products. Selected citations for Sarcosine include:

Yoshikawa et al (2012) Glycine transporter type 2 (GlyT2) inhibitor ameliorates bladder overactivity and nociceptive behavior in rats. Eur Urol 62 704. PMID: 22341128.

Do you know of a great paper that uses Sarcosine from Tocris? If so please let us know.

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Keywords: Sarcosine, supplier, GlyT1, inhibitors, inhibits, Glycine, Transporters, Monoamine, Neurotransmitter, Tocris Bioscience, Glycine Transporter Inhibitor products

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