Cat. No. 2969
Chemical Name: [[3,5-Bis(1,1-dimethylethyl)-4-hydr
Biological ActivityPregnane X receptor (PXR) agonist (EC50 values are 200 and 700 nM for human and rabbit PXR respectively). Activates the farnesoid X receptor (FXR) at μM concentrations. Displays hypocholesterolaemic activity via enchanced degradation of HMG-CoA reductase.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Lemaire et al (2007) Discovery of a highly active ligand of human pregnane X receptor: a case study from pharmacophore modeling and virtual screening to "in vivo" biological activity. Mol.Pharmacol. 72 572. PMID: 17573484.
Jones et al (2000) The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution. Mol.Pharmacol. 14 27.
Berkhout et al (1996) The novel cholesterol-lowering drug SR-12813 inhibits cholesterol synthesis via an increased degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase J.Biol.Chem. 271 14376. PMID: 8662919.
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Keywords: SR 12813, supplier, Pregnane, X, receptor, PXR, agonists, Nuclear, Receptors, SR12813, Tocris Bioscience, Pregnane X Receptor Agonist products