Spironolactone

Cat. No. 2968

Spironolactone C24H32O4S [52-01-7]

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Alternative Names: SC 9420, Aldactone

Chemical Name: (7α,17α)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid γ-lactone

Biological Activity

Competitive mineralocorticoid (aldosterone) receptor antagonist that exhibits antihypertensive activity in vivo. Also displays antiandrogen activity and inhibits steroid hormone biosynthesis.

Technical Data

M.Wt:
416.57
Formula:
C24H32O4S
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>98 %
Storage:
Store at RT
CAS No:
52-01-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Ye et al (2009) Contrasting effects of eplerenone and spironolactone on adrenal cell steroidogenesis. Horm.Metab.Res. 41 35. PMID: 18819053.

Struthers et al (2008) A comparison of the aldosterone-blocking agents eplernone and spironolactone. Clin.Cardiol. 31 153. PMID: 18404673.

Delyani et al (2000) Mineralocorticoid receptor antagonists: the evolution of utility and pharmacology. Kidney Int. 57 1408. PMID: 10760075.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Spironolactone include:

Liu et al (2014) Chronic stress impairs GABAergic control of amygdala through suppressing the tonic GABAA receptor currents. Mol Brain 7 32. PMID: 24758222.

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Keywords: Spironolactone, supplier, Anti-Androgen, AntiAndrogen, inhibits, inhibitors, steroid, hormone, biosynthesis, MR, antagonists, Mineralocorticoid, receptor, Dihydrotestosterone, Receptors, Androgen, Aldosterone, SC9420, Tocris Bioscience, Mineralocorticoid Receptor Antagonist products

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