Phenserine

Cat. No. 2967

Phenserine C20H23N3O2 [101246-66-6]

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Chemical Name: (3aS,8aR)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol 5-(N-phenylcarbamate)

Biological Activity

Physostigmine analog that inhibits acetylcholinesterase. Inhibits production of amyloid precursor protein (APP) and Aβ. Improves morris water maze performance of scopolamine-treated rats.

Technical Data

M.Wt:
337.42
Formula:
C20H23N3O2
Solubility:
Soluble to 10 mM in DMSO and to 25 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
101246-66-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Klein (2007) Phenserine. Expert Opin.Investig.Drugs 16 1087. PMID: 17594192.

Utsuki et al (2006) Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer's disease amyloid-β peptide. J.Pharmacol.Exp.Ther. 318 855. PMID: 16690718.

Janas et al (2005) The cholinesterase inhibitor, phenserine, improves morris water maze performance of scopolamine-treated rats. Life Sci. 76 1073. PMID: 15620572.

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Keywords: Phenserine, supplier, Cholinesterase, inhibitors, inhibits, AChE, Acetylcholinesterase, Esterases, Acetylcholine, Nicotinic, Receptors, nAChR, Muscarinic, Tocris Bioscience, Cholinesterase Inhibitor products

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