Cat. No. 2967
Chemical Name: (3aS,8aR)-1,2,3,3a,8,8a-Hexahydro-1
Biological ActivityPhysostigmine analog that inhibits acetylcholinesterase. Inhibits production of amyloid precursor protein (APP) and Aβ. Improves morris water maze performance of scopolamine-treated rats.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Klein (2007) Phenserine. Expert Opin.Investig.Drugs 16 1087. PMID: 17594192.
Utsuki et al (2006) Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer's disease amyloid-β peptide. J.Pharmacol.Exp.Ther. 318 855. PMID: 16690718.
Janas et al (2005) The cholinesterase inhibitor, phenserine, improves morris water maze performance of scopolamine-treated rats. Life Sci. 76 1073. PMID: 15620572.
If you know of a relevant reference for Phenserine please let us know.
Citations are publications that use Tocris products. Selected citations for Phenserine include:
Elgueta et al (2015) Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells. Sci Rep 9 6. PMID: 25709566.
Do you know of a great paper that uses Phenserine from Tocris? If so please let us know.
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Keywords: Phenserine, supplier, Cholinesterase, inhibitors, inhibits, AChE, Acetylcholinesterase, Esterases, Acetylcholine, Nicotinic, Receptors, nAChR, Muscarinic, Tocris Bioscience, Cholinesterase Inhibitor products