CGP 3466B maleate

Cat. No. 2966

CGP 3466B maleate C19H17NO.C4H4O4 [200189-97-5]

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Alternative Name: TCH 346 maleate

Chemical Name: N-(Dibenz[b,f]oxepin-10-ylmethyl)-N-Methyl-N-(2-propynyl)amine maleate

Biological Activity

Orally active glyceraldehyde-3-phosphate dehydrogenase (GAPDH) inhibitor. Exhibits antiapoptotic activity via inhibition of GAPDH nuclear translocation and mitochondrial complex 1-dependent H2O2 release. Displays neuroprotective activity in vivo.

Technical Data

M.Wt:
391.42
Formula:
C19H17NO.C4H4O4
Solubility:
Soluble to 10 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
200189-97-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Zoccarato et al (2008) Clorgyline and other propargylamine derivatives as inhibitors of succinate-dependent H2O2 release at NADH:UBIQUINONE oxidoreductase (Complex I) in brain mitochondria. J.Bioenerg.Biomembr. 40 289. PMID: 18763029.

Andringa et al (2003) TCH346 prevents motor symptoms and loss of striatal FDOPA uptake in bilaterally MPTP-treated primates. Neurobiol.Dis. 14 205. PMID: 14572443.

Sagot et al (2000) An orally active anti-apoptotic molecule (CGP 3466B) preserves mitochondria and enhances survival in an animal model of motoneuron disease. Br.J.Pharmacol. 131 721. PMID: 11030721.

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Keywords: CGP 3466B maleate, supplier, glyceraldehyde-3-phosphate, dehydrogenase, GAPDH, inhibitors, inhibits, CGP3466B, TCH346, Tocris Bioscience, Other Dehydrogenase Inhibitor products

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