FPA 124

Cat. No. 2926

FPA 124 C11H9Cl2CuN3O2S [902779-59-3]

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Chemical Name: Dichloro[(2Z)-2-[(4-oxo-4H-1-benzopyran-3-yl)methylene]hydrazinecarbothioamide copper complex

Biological Activity

Akt/PKB inhibitor (IC50 = 100 nM) that interacts with the PH and kinase domains. Inhibits cell proliferation in various cancer cell lines in vitro and decreases NF-κB activity and tumor load in vivo.

Technical Data

M.Wt:
381.73
Formula:
C11H9Cl2CuN3O2S
Solubility:
Soluble to 10 mM in DMSO and to 10 mM in ethanol
Storage:
Store at +4°C
CAS No:
902779-59-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service

References are publications that support the products' biological activity.

Barve et al (2006) Synthesis, molecular characterization, and biological activity of novel synthetic derivatives of chromen-4-one in human cancer cells. J.Med.Chem. 49 3800. PMID: 16789737.

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Keywords: FPA 124, supplier, Akt, PKB, inhibitors, inhibits, Protein, Kinases, B, FPA124, Tocris Bioscience, Akt (Protein Kinase B) Inhibitor products

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