Cat. No. 2926
Chemical Name: Dichloro[(2Z)-2-[(4-oxo-4H-1-benzop
Biological ActivityAkt/PKB inhibitor (IC50 = 100 nM) that interacts with the PH and kinase domains. Inhibits cell proliferation in various cancer cell lines in vitro and decreases NF-κB activity and tumor load in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
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Barve et al (2006) Synthesis, molecular characterization, and biological activity of novel synthetic derivatives of chromen-4-one in human cancer cells. J.Med.Chem. 49 3800. PMID: 16789737.
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Keywords: FPA 124, supplier, Akt, PKB, inhibitors, inhibits, Protein, Kinases, B, FPA124, Tocris Bioscience, Akt (Protein Kinase B) Inhibitor products
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