Doxazosin mesylate

Cat. No. 2964

Doxazosin mesylate C23H25N5O5.CH3SO3H [77883-43-3]

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Alternative Name: UK 33274

Chemical Name: 4-Amino-2-[4-(1,4-benzodioxan-2-carbonyl)piperazin-1-yl]-6,7-dimethoxyquinazoline methanesulfonate

Biological Activity

Selective α1-adrenoceptor antagonist (pKi values are 9.0, 8.5 and 8.4 for human α1B, α1A and α1D receptors respectively). Displays antihypertensive activity.

Technical Data

M.Wt:
547.58
Formula:
C23H25N5O5.CH3SO3H
Solubility:
Soluble to 75 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
77883-43-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Ma et al (2006) Chiral selective effects of doxazosin enantiomers on blood pressure and urinaruy bladder pressure in anesthetized rats. Acta Pharmacol.Sinica 27 1423.

Kenny et al (1996) Evaluation of the pharmacological selectivity profile of α1 adrenoceptor antagonists at prostatic α1 adrenoceptors: binding functional and in vivo studies. Br.J.Pharmacol. 118 871. PMID: 8799556.

Alabaster and Davey (1986) The α1-adrenoceptor antagonist profile of doxazosin: preclinical pharmacology. Br.J.Clin.Pharmacol. 21 9S. PMID: 2871857.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Doxazosin mesylate include:

Jahchan et al (2013) A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors. Cancer Discov 3 1364. PMID: 24078773.

Do you know of a great paper that uses Doxazosin mesylate from Tocris? If so please let us know.

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Keywords: Doxazosin mesylate, supplier, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenergic, α1-adrenergic, alpha1-adrenergic, a1-adrenoceptor, antagonists, Receptors, UK33274, Tocris Bioscience, Adrenergic α1 Receptor Antagonist products

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