Cat. No. 2964
Alternative Name: UK 33274
Chemical Name: 4-Amino-2-[4-(1,4-benzodioxan-2-car
Biological ActivitySelective α1-adrenoceptor antagonist (pKi values are 9.0, 8.5 and 8.4 for human α1B, α1A and α1D receptors respectively). Displays antihypertensive activity.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Ma et al (2006) Chiral selective effects of doxazosin enantiomers on blood pressure and urinaruy bladder pressure in anesthetized rats. Acta Pharmacol.Sinica 27 1423.
Kenny et al (1996) Evaluation of the pharmacological selectivity profile of α1 adrenoceptor antagonists at prostatic α1 adrenoceptors: binding functional and in vivo studies. Br.J.Pharmacol. 118 871. PMID: 8799556.
Alabaster and Davey (1986) The α1-adrenoceptor antagonist profile of doxazosin: preclinical pharmacology. Br.J.Clin.Pharmacol. 21 9S. PMID: 2871857.
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Citations are publications that use Tocris products. Selected citations for Doxazosin mesylate include:
Diaz et al (2014) Moderate Alcohol Exposure during the Rat Equivalent to the Third Trimester of Human Pregnancy Alters Regulation of GABAA Receptor-Mediated Synaptic Transmission by Dopamine in the Basolateral Amygdala. Front Cell Neurosci 2 46. PMID: 24904907.
Jahchan et al (2013) A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors. Cancer Discov 3 1364. PMID: 24078773.
Do you know of a great paper that uses Doxazosin mesylate from Tocris? If so please let us know.
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Keywords: Doxazosin mesylate, supplier, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenergic, α1-adrenergic, alpha1-adrenergic, a1-adrenoceptor, antagonists, Receptors, UK33274, Tocris Bioscience, Adrenergic α1 Receptor Antagonist products
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Selective, high affinity, non-competitive α1A adrenoceptor antagonist
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