MMPIP hydrochloride

Cat. No. 2963

MMPIP hydrochloride C19H15N3O3.HCl [479077-02-6]

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Chemical Name: 6-(4-Methoxyphenyl)-5-methyl-3-(4-pyridinyl)-isoxazolo[4,5-c]pyridin-4(5H)-one hydrochloride

Biological Activity

Potent allosteric mGlu7-selective receptor antagonist. Inhibits agonist-induced intracellular calcium mobilization and cAMP accumulation (IC50 values are 26 and 610 nM). Displays intrinsic activity; increases forskolin-induced cAMP accumulation in the absence of an agonist (IC50 = 15 nM), indicating inverse agonist activity.

Technical Data

M.Wt:
369.8
Formula:
C19H15N3O3.HCl
Solubility:
Soluble to 10 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
479077-02-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Suzuki et al (2007) In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists. J.Pharmacol.Exp.Ther. 323 147. PMID: 17609420.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for MMPIP hydrochloride include:

Johansson et al (2015) Activation of a temporal memory in purkinje cells by the mGluR7 receptor. Cell Rep. 13 1741. PMID: 26655894.

Kammermeier (2015) Constitutive activity of metabotropic glutamate receptor 7. Front Pediatr 16 17. PMID: 25881041.

Do you know of a great paper that uses MMPIP hydrochloride from Tocris? If so please let us know.

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Keywords: MMPIP hydrochloride, supplier, Potent, allosteric, mGlu7, mGluR7-selective, antagonists, Group, III, Receptors, Glutamate, Metabotropic, Tocris Bioscience, Glutamate (Metabotropic) Group III Receptor Antagonist products

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