Cat. No. 2963
Chemical Name: 6-(4-Methoxyphenyl)-5-methyl-3-(4-p
Biological ActivityPotent allosteric mGlu7-selective receptor antagonist. Inhibits agonist-induced intracellular calcium mobilization and cAMP accumulation (IC50 values are 26 and 610 nM). Displays intrinsic activity; increases forskolin-induced cAMP accumulation in the absence of an agonist (IC50 = 15 nM), indicating inverse agonist activity.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Suzuki et al (2007) In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists. J.Pharmacol.Exp.Ther. 323 147. PMID: 17609420.
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Citations are publications that use Tocris products. Selected citations for MMPIP hydrochloride include:
Johansson et al (2015) Activation of a temporal memory in purkinje cells by the mGluR7 receptor. Cell Rep. 13 1741. PMID: 26655894.
Kammermeier (2015) Constitutive activity of metabotropic glutamate receptor 7. Front Pediatr 16 17. PMID: 25881041.
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Keywords: MMPIP hydrochloride, supplier, Potent, allosteric, mGlu7, mGluR7-selective, antagonists, Group, III, Receptors, Glutamate, Metabotropic, Tocris Bioscience, Glutamate (Metabotropic) Group III Receptor Antagonist products
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Negative allosteric modulator at mGlu7; brain penetrant
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