Cat. No. 2937
Chemical Name: 5-(2-Ethyl-2,3-dihydro-1H-indene-2-
Biological ActivitySelective α2-adrenergic receptor antagonist (Ki values are 1.1, 1.0, 0.89, 1300 and 6500 nM for α2A, α2B, α2C, α1A and α1B receptors respectively). Brain penetrant.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Jurgens et al (2007) α2A adrenergic receptor activation inhibits epileptiform activity in the rat hippocampal CA3 region. Mol.Pharmacol. 71 1572. PMID: 17341653.
Puurunen et al (2001) An α2-adrenergic antagonist, atipamezole, facilitates behavioral recovery after focal cerebral ischemia in rats. Neuropharmacology 40 597. PMID: 11249969.
Virtanen et al (1989) Highly selective and specific antagonism of central and peripheral alpha 2-adrenoceptors by atipamezole. Arch.Int.Pharmacodyn.Ther. 297 190. PMID: 2567152.
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