Cat. No. 2961
Alternative Name: BB-94
Chemical Name: (2R,3S)-N4-Hydroxy-N1-[(1S)-2-(meth
Biological ActivityPotent, broad spectrum MMP inhibitor (IC50 values are 3, 4, 4, 6 and 20 nM for MMP -1, -2, -9, -7 and -3 respectively). Exhibits antiproliferative, anti-invasive and antimetastatic activity in human ovarian carcinoma xenografts in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kohn and Liotta (1995) Molecular insights into cancer invasion: strategies for prevention and intervention. Cancer Res. 55 1856. PMID: 7728753.
Wang et al (1994) Matrix metalloproteinase inhibitor BB-94 (Batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice. Cancer Res. 54 4726. PMID: 8062271.
Davies et al (1993) A synthetic matrix metalloproteinase inhibitor decreases tumor burden and prolongs survival of mice bearing human ovarian carcinoma xenografts. Cancer Res. 53 2087. PMID: 8347186.
If you know of a relevant reference for Batimastat please let us know.
Citations are publications that use Tocris products. Selected citations for Batimastat include:
Esteso et al (2014) Altered microRNA expression after infection with human cytomegalovirus leads to TIMP3 downregulation and increased shedding of metalloprotease substrates, including MICA. J Immunol 193 1344. PMID: 24973455.
Feng et al (2014) Epithelial innate immune response to Acinetobacter baumannii challenge. Br J Cancer 82 4458. PMID: 25114113.
Ji et al (2014) EphrinB2 affects apical constriction in Xenopus embryos and is regulated by ADAM10 and flotillin-1. Nat Commun 5 3516. PMID: 24662724.
Brafman et al (2013) Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions. Korean J Physiol Pharmacol 20 369. PMID: 23154389.
Woods and Padmanabhan (2013) Inhibition of amyloid precursor protein processing enhances gemcitabine-mediated cytotoxicity in pancreatic cancer cells. J Biol Chem 288 30114. PMID: 24022491.
Yoo et al (2013) TNF-α and LPA promote synergistic expression of COX-2 in human colonic myofibroblasts: role of LPA-mediated transactivation of upregulated EGFR. Infect Immun 13 90. PMID: 23688423.
Jijon et al (2012) The EGF receptor and HER2 participate in TNF-α-dependent MAPK activation and IL-8 secretion in intestinal epithelial cells. Mediators Inflamm 2012 207398. PMID: 22988345.
Kalous et al (2012) Neurotrophic actions initiated by proNGF in adult sensory neurons may require peri-somatic glia to drive local cleavage to NGF. J Neurochem 122 523. PMID: 22621370.
Mezil et al (2012) Tumor selective cytotoxic action of a thiomorpholin hydroxamate inhibitor (TMI-1) in breast cancer. PLoS One 7 e43409. PMID: 23028451.
Prendergast et al (2012) The metalloproteinase inhibitor Reck is essential for zebrafish DRG development. BMC Gastroenterol 139 1141. PMID: 22296847.
Yin et al (2012) Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones. Am J Physiol Endocrinol Metab 303 E55. PMID: 22496348.
Yurtsever et al (2012) Self-cleavage of human CLCA1 protein by a novel internal metalloprotease domain controls calcium-activated chloride channel activation. Development 287 42138. PMID: 23112050.
Dang et al (2011) Epidermal growth factor (EGF) ligand release by substrate-specific a disintegrin and metalloproteases (ADAMs) involves different protein kinase C (PKC) isoenzymes depending on the stimulus. J Biol Chem 286 17704. PMID: 21454702.
Hamasaki et al (2011) Expression of laminin 5-γ2 chain in cutaneous squamous cell carcinoma and its role in tumour invasion. Cell Commun Signal 105 824. PMID: 21829200.
Kim et al (2011) Thrombin-induced Migration and Matrix Metalloproteinase-9 Expression Are Regulated by MAPK and PI3K Pathways in C6 Glioma Cells. J Biol Chem 15 211. PMID: 21994479.
Kwon et al (2011) Notch post-translationally regulates β-catenin protein in stem and progenitor cells. Nat Cell Biol 13 1244. PMID: 21841793.
Park et al (2011) Matrix metalloproteinase inhibitors attenuate neuroinflammation following focal cerebral ischemia in mice. Korean J Physiol Pharmacol 15 115. PMID: 21660152.
Sims et al (2011) Extracellular heat shock protein (Hsp)70 and Hsp90α assist in matrix metalloproteinase-2 activation and breast cancer cell migration and invasion. PLoS One 6 e18848. PMID: 21533148.
Walsh and Damjanovski (2011) IGF-1 increases invasive potential of MCF 7 breast cancer cells and induces activation of latent TGF-β1 resulting in epithelial to mesenchymal transition. BMC Neurosci 9 10. PMID: 21535875.
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Keywords: Batimastat, supplier, Potent, broad, spectrum, MMP, inhibitors, inhibits, Matrixins, Matrix, Metalloproteinase, Metalloprotease, Proteinases, Proteases, Tocris Bioscience, Matrix Metalloprotease Inhibitor products
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