Felodipine

Cat. No. 2960

Felodipine C18H19Cl2NO4 [72509-76-3]

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Chemical Name: 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester

Biological Activity

L-type Ca2+ channel blocker that is selective over N-, R-, P/Q- and T-type channels. Displays high vascular selectivity; lowers arterial blood pressure without altering cardiac contractility. Antihypertensive.

Technical Data

M.Wt:
384.25
Formula:
C18H19Cl2NO4
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
72509-76-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Furukawa et al (2005) Differential blocking action of dihydropyridine Ca2+ antagonists on a T-type Ca2+ channel (α1G) expressed in Xenopus oocytes. J.Cardiovasc.Pharmacol. 45 241. PMID: 15725949.

Furukawa et al (1999) Selectivities of dihydropyridine derivatives in blocking Ca2+ channel subtypes expressed in Xenopus oocytes. J.Pharmacol.Exp.Ther. 291 464. PMID: 10525060.

Ljung (1990) Vascular selectivity of felodipine: experimental pharmacology. J.Cardiovasc.Pharmacol. 15 S11. PMID: 1693715.

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Keywords: Felodipine, supplier, Ca2+, channel, blockers, L-type, Calcium, CaV, Channels, L-Type, voltage-gated, voltage-dependent, Tocris Bioscience, Voltage-gated Calcium Channel (CaV) Blocker products

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