Lercanidipine hydrochloride

Cat. No. 2959

Lercanidipine hydrochloride C36H41N3O6.HCl [132866-11-6]

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Chemical Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl methyl ester hydrochloride

Biological Activity

L-type Ca2+ channel blocker that displays higher vascular selectivity than felodipine (Cat. No. 2960). Causes peripheral vasodilation with only weak negative inotropic activity. Antihypertensive.

Technical Data

Soluble to 100 mM in DMSO and to 10 mM in ethanol
>99 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Wirtz and Herzig (2004) Molecular mechanisms of vasoselectivity of the 1,4-dihydropyridine lercanidipine. Br.J.Pharmacol. 142 275. PMID: 15155536.

Bang et al (2003) Lercanidipine. A review of its efficacy in the management of hypertension. Drugs 63 2449. PMID: 14609358.

Sironi et al (1996) Antihypertensive effects of lercanidipine in experimental hypertensive rats and dogs. Arzneim.Forsch. 46 152.

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Keywords: Lercanidipine hydrochloride, supplier, Ca2+, channel, blockers, L-type, Calcium, CaV, Channels, L-Type, voltage-gated, voltage-dependent, Tocris Bioscience, Voltage-gated Calcium Channel (CaV) Blocker products

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