Cat. No. 2958

DSP-4 C11H15BrClN.HCl [40616-75-9]

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Chemical Name: N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride

Biological Activity

Adrenergic neurotoxin. Displays neurotoxic effects on both peripheral and central noradrenergic neurons.

Technical Data

Soluble to 100 mM in water and to 100 mM in ethanol
>98 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Kawamura et al (2005) Short and long term analysis of heart rate variations in spontaneous hypertensive rats: effect of DSP-4 administration. Biomed.Pharmacother. 59 S203. PMID: 16275495.

Haidkind et al (2002) Denervation of the locus coeruleus projections by treatment with the selective neurotoxin DSP-4 [N(2-chloroethyl)-N-ethyl-2-bromobenzylamine] reduces dopamine release potential in the nucleus accumbens shell in conscious rats. Neurosci.Letts. 332 79.

Jaim-Etcheverry and Zieher (1980) DSP-4: a novel compound with neurotoxic effects on noradrenergic neurons of adult and developing rats. Brain Res. 188 513. PMID: 7370771.

If you know of a relevant reference for DSP-4 please let us know.

Citations are publications that use Tocris products. Selected citations for DSP-4 include:

Li et al (2015) Analgesic Effects of Bee Venom Derived Phospholipase A(2) in a Mouse Model of Oxaliplatin-Induced Neuropathic Pain. Toxins (Basel) 7 2422. PMID: 26131771.

Coura et al (2013) Nonaggressive and adapted social cognition is controlled by the interplay between noradrenergic and nicotinic receptor mechanisms in the prefrontal cortex. FASEB J 27 4343. PMID: 23882123.

Do you know of a great paper that uses DSP-4 from Tocris? If so please let us know.

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Keywords: DSP-4, supplier, Adrenergic, neurotoxin, Compounds, Adrenoceptors, Receptors, noradrenergic, neurons, neurotoxins, Tocris Bioscience, Adrenergic Related products

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