Cat. No. 2956
Alternative Name: Picropodophyllin
Chemical Name: (5R,5aS,8aR,9R)-5,8,8a,9-Tetrahydro
Biological ActivityOrally active insulin-like growth factor 1 receptor (IGF1R) inhibitor that exhibits no activity at the insulin receptor, FGFR, PDGFR or EGFR. Inhibits IGF1R autophosphorylation (IC50 ~ 1 nM), increases the fraction of cells in the G2/M phase and upregulates apoptosis. Exhibits antiproliferative effects in multiple cancer cell lines (IC50 = 0.05 - 15 μM), and has anticancer and antineovascularization activity in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Economou et al (2008) Inhibition of VEGF secretion and experimental choroidal neovascularization by picropodophyllin (PPP), an inhibitor of the insulin-like growth factor-1 receptor. Invest.Ophthalmol.Vis.Sci. 49 2620. PMID: 18515591.
Stromberg et al (2006) IGF-1 receptor tyrosine kinase inhibition by the cyclolignan PPP induces G2/M-phase accumulation and apoptosis in multiple myeloma cells. Blood 107 669. PMID: 16166596.
Girnita et al (2004) Cyclolignans as inhibitors of the insulin-like growth factor-1 receptor and malignant cell growth. Cancer Res. 64 236. PMID: 14729630.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for Picropodophyllotoxin include:
Stouffer et al (2015) Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward. Nat Commun 6 8543. PMID: 26503322.
Do you know of a great paper that uses Picropodophyllotoxin from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: Picropodophyllotoxin, supplier, Selective, IGF1R, inhibitors, inhibits, Receptors, Insulin-like, Receptor, Tyrosine, Kinases, RTKs, Picropodopyhllin, Tocris Bioscience, Insulin and Insulin-like Receptors Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent and selective pan-Trk inhibitor; peripherally restrictedHIOC
Selective TrkB receptor agonist; neuroprotectantAV 412
Potent inhibitor of EGFR, ErbB2 and Abl receptor tyrosine kinasesCP 724714
Potent and selective ErbB2 inhibitor
Follow Tocris on LinkedIn
Visit our LinkedIn page for the latest Tocris news, events and updates.