Cat. No. 2954
Alternative Name: IV-2
Chemical Name: 2-[(1-Methylpropyl)dithio]-1H-imida
Biological ActivityThioredoxin-1 (Trx-1) inhibitor; irreversibly inactivates Trx-1 as a substrate for reduction by thioredoxin reductase (TR); competitively inhibits the reduction of Trx-1 by TR (Ki = 30.8 μM). Attenuates expression of HIF-1α, VEGF and iNOS (IC50 values are 7.2, 10.4 and 18.1 μM respectively). Exhibits antitumor activity; directly inhibits tubulin in vitro and decreases tumor microvessel density in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Jordan et al (2005) The thioredoxin-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide (PX-12) decreases vascular permeability in tumor xenografts monitored by dynamic contrast enhanced magnetic resonance imaging. Clin.Cancer Res. 11 529. PMID: 15701837.
Welsh et al (2003) The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1α and vascular endothelial growth factor formation. Mol.Cancer.Ther. 2 235. PMID: 12657718.
Kirkpatrick et al (1998) Mechanisms of inhibition of the thioredoxin growth factor system by antitumor 2-imidazolyl disulfides. Biochem.Pharmacol. 55 987. PMID: 9605422.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for PX 12 include:
Zhu et al (2012) BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells. Cell Death Differ 31 31. PMID: 22463935.
Do you know of a great paper that uses PX 12 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: PX 12, supplier, px12, thioredoxin-1, trx-1, inhibitors, inhibits, HIF-1alpha, HIF-1a, HIF-1α, IV-2, antiangiogenics, Tocris Bioscience, Other Reductase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Protein disulfide isomerase (PDI) inhibitor3-AP
Ribonucleotide reductase inhibitor; also an iron chelator
Win a $1,000 travel grant
Bio-Techne is offering 10 travel grants of $1,000 for AACR 2017.