PX 12

Cat. No. 2954

PX 12 C7H12N2S2 [141400-58-0]

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Alternative Name: IV-2

Chemical Name: 2-[(1-Methylpropyl)dithio]-1H-imidazole

Biological Activity

Thioredoxin-1 (Trx-1) inhibitor; irreversibly inactivates Trx-1 as a substrate for reduction by thioredoxin reductase (TR); competitively inhibits the reduction of Trx-1 by TR (Ki = 30.8 μM). Attenuates expression of HIF-1α, VEGF and iNOS (IC50 values are 7.2, 10.4 and 18.1 μM respectively). Exhibits antitumor activity; directly inhibits tubulin in vitro and decreases tumor microvessel density in vivo.

Technical Data

M.Wt:
188.31
Formula:
C7H12N2S2
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
141400-58-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Jordan et al (2005) The thioredoxin-1 inhibitor 1-methylpropyl 2-imidazolyl disulfide (PX-12) decreases vascular permeability in tumor xenografts monitored by dynamic contrast enhanced magnetic resonance imaging. Clin.Cancer Res. 11 529. PMID: 15701837.

Welsh et al (2003) The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1α and vascular endothelial growth factor formation. Mol.Cancer.Ther. 2 235. PMID: 12657718.

Kirkpatrick et al (1998) Mechanisms of inhibition of the thioredoxin growth factor system by antitumor 2-imidazolyl disulfides. Biochem.Pharmacol. 55 987. PMID: 9605422.

If you know of a relevant reference for PX 12 please let us know.

Citations are publications that use Tocris products. Selected citations for PX 12 include:

Zhu et al (2012) BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells. Cell Death Differ 31 31. PMID: 22463935.

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Keywords: PX 12, supplier, px12, thioredoxin-1, trx-1, inhibitors, inhibits, HIF-1alpha, HIF-1a, HIF-1α, IV-2, antiangiogenics, Tocris Bioscience, Other Reductase Inhibitor products

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