PAF (C16)

Cat. No. 2940

PAF (C16) C26H54NO7P [74389-68-7]

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Alternative Name: Platelet-activating factor

Chemical Name: (7R)-7-(Acetyloxy)-4-hydroxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphapentacosan-1-aminium-4-oxide

Biological Activity

Endogenous platelet-activating factor (PAF) and ligand for PAF receptors. Produced by inflammatory cells and a potent chemoattractant for polymorphonuclear neutrophils. Induces increased vascular permeability.

Technical Data

M.Wt:
523.68
Formula:
C26H54NO7P
Solubility:
Soluble to 100 mM in water and to 100 mM in ethanol
Storage:
Desiccate at -20°C
CAS No:
74389-68-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Handa et al (1991) Vasorelaxant effect of C16-PAF and C18-PAF on renal blood flow and systemic blood pressure in the anesthetized rat. Life Sci. 49 747. PMID: 1875784.

Archer et al (1988) Actions of platelet activating factor (PAF) homologues and their combinations on neutrophil chemokinesis and cutaneous inflammatory responses in man. J.Invest.Dermatol. 91 82. PMID: 3385217.

Oda et al (1985) Molecular species of platelet-activating factor generated by human neutrophils challenged with ionophore A23187. J.Immunol. 134 1090. PMID: 3917470.

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Keywords: PAF (C16), supplier, Endogenous, platelet-activating, factor, PAF, Receptors, Platelet-activating, Factor, Tocris Bioscience, Platelet-Activating Factor (PAF) Receptor Agonist products

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