Stressin I

Cat. No. 1608

Stressin I Ac-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-cyclo(γ-Glu-His-Ser-ε-Lys)-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2

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Alternative Name: cyclo(31-34)[D-Phe12,Nle21,38,Glu31, Lys34]Ac-hCRF (4-41)

Biological Activity

Potent and selective corticotropin releasing factor receptor-1 (CRF1) agonist (Ki values are 1.5 and 224 nM for CRF1 and CRF2 receptors respectively). Increases ACTH levels and increases faecal pellet output in vivo following i.p. administration.

Licensing Information

Sold with the permission of the SALK Institute

Technical Data

M.Wt:
4472.24
Formula:
C203H337N57O56
Sequence:
PPISLDLTFHLLREVLEXARAEQLAQQEHSKRKLXEII

(Modifications: Pro-1 = N-terminal Ac, X = Nle, Glu-28 = γ-Glu, Lys-31 = ε-Lys, Cyclized = Glu-28 - Lys-31, Ile-38 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Bruchas et al (2009) CRF1-R activation of the dynorphin/kappa opioid system in the mouse basolateral amygdala mediates anxiety-like behavior. PLoS One. 4 e8528. PMID: 20052275.

Rivier et al (2007) Stressin1-A, a potent corticotropin releasing factor receptor 1 (CRF1)-selective peptide agonist. J.Med.Chem. 50 1668. PMID: 17335188.

Rivier et al (2002) Receptor-selective corticotropin releasing factor analogs. Endocrin.Soc.Abstr. P2-50.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Stressin I include:

Land et al (2008) The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system. J Neurosci 28 407. PMID: 18184783.

Do you know of a great paper that uses Stressin I from Tocris? If so please let us know.

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Keywords: Stressin I, supplier, CRF1, agonists, Corticotropin-Releasing, Factor1, Receptors, Factor, StressinI, Tocris Bioscience, CRF1 Receptor Agonist products

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