Astressin

Cat. No. 1606

Astressin D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-cyclo(-γ-Glu-Ala-His-ε-Lys)-Asn-Arg-Lys-Leu-Nle-Glu-Ile-Ile-NH2

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Alternative Name: [D-Phe12, Nle21,38, Glu30, Lys33]-CRF (12-41)

Biological Activity

Potent corticotropin-releasing factor (CRF) receptor antagonist (Ki values are 2, 1.5 and 1 nM at CRF1, CRF2α and CRF2β). Reduces ACTH secretion, blocks delayed gastric emptying and is neuroprotective in vivo.

Licensing Information

Sold with the permission of the SALK Institute

Technical Data

M.Wt:
3563.2
Formula:
C161H269N49O42
Sequence:
FHLLREVLEXARAEQLAQEAHKNRKLXEII

(Modifications: Phe-1 = D-Phe, X = Nle, Glu-19 = γ-Glu, Lys-22 = ε-Lys, Cyclized = Glu-19 -Lys-22, Ile-31 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in 10% Acetic acid / water
Storage:
Store at -20°C
CAS No:
170809-51-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Martinez et al (1999) Peripheral injection of a new corticotropin-releasing factor (CRF) antagonist, astressin, blocks peripheral CRF- and abdominal surgery-induced delayed gastric emptying in rats. J.Pharmacol.Exp.Ther. 290 629. PMID: 10411571.

Perrin and Vale (1999) Corticotropin releasing factor receptors and their ligand family. Ann.N.Y.Acad.Sci. 885 312. PMID: 10816663.

Maecker et al (1997) Astressin, a novel and potent CRF antagonist, is neuroprotective in the hippocampus when administered after a seizure. Brain Res. 744 166. PMID: 9030428.

Gulyas et al (1995) Potent, structurally constrained agonists and competitive antagonists of corticotropin-releasing factor. Proc.Natl.Acad.Sci.U.S.A. 92 10575. PMID: 7479843.

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Keywords: Astressin, supplier, Potent, CRF, receptor, antagonists, Corticotropin-Releasing, Factor, Non-Selective, Receptors, Tocris Bioscience, Non-selective CRF Receptor Antagonist products

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