NBMPR

Cat. No. 2924

NBMPR C17H17N5O6S [38048-32-7]

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Chemical Name: 6-S-[(4-Nitrophenyl)methyl]-6-thioinosine

Biological Activity

Equilibrative nucleoside transporter 1 (ENT1) inhibitor (Ki values are 0.4 and 2800 nM for hENT1 and hENT2 respectively).

Technical Data

M.Wt:
419.41
Formula:
C17H17N5O6S
Solubility:
Soluble to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
38048-32-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Lin and Buolamwini (2007) Synthesis and flow cytometric evaluation, and identification of highly potent dipyridamole analogues as equilibrative nucleoside transporter 1 inhibitors. J.Med.Chem. 50 3906. PMID: 17636949.

Tsujie et al (2007) Human equilibrative nucleoside transporter 1, as a predictor of 5-fluorouracil resistance in human pancreatic cancer. Anticancer Res. 27 2241. PMID: 17695509.

Ward et al (2000) Kinetic and pharmacological properties of cloned human equilibrative nucleoside transporters, ENT1 and ENT2, stably expressed in nucleoside transporter-deficient PK15 cells. J.Biol.Chem. 275 8375. PMID: 10722669.

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Citations are publications that use Tocris products. Selected citations for NBMPR include:

Clasadonte et al (2014) Chronic sleep restriction disrupts sleep homeostasis and behavioral sensitivity to alcohol by reducing the extracellular accumulation of adenosine. J Neurosci 34 1879. PMID: 24478367.

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Keywords: NBMPR, supplier, Equilibrative, nucleoside, transporter, 1, ENT1, inhibitors, inhibits, adenosines, reuptake, Purine, Transporters, Pyrimidine, Nucleoside, Monoamine, Neurotransmitter, NBTI, Tocris Bioscience, Nucleoside Transporter Inhibitor products

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