Ro 32-3555

Cat. No. 2916

Ro 32-3555 C22H36N4O5 [190648-49-8]

Price and Availability

For Ro 32-3555 pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: (αR,βR)-β-(Cyclopentylmethyl)-N-hydroxy-γ-oxo-α-[(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-1-piperidinebutanamide

Biological Activity

Potent, collagenase-selective MMP inhibitor (Ki values are 3.0, 3.4, 4.4, 59, 154 and 527 nM for MMP-1, MMP-13, MMP-8, MMP-9, MMP-2 and MMP-3 respectively). Inhibits cartilage breakdown in vitro and in vivo and displays antiarthritic activity. Orally active.

Technical Data

M.Wt:
436.55
Formula:
C22H36N4O5
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>97 %
Storage:
Store at -20°C
CAS No:
190648-49-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

Brewster et al (1998) Ro 32-3555, an orally active collagenase selective inhibitor, prevents structural damage in the SRT/ORT mouse model of osteoarthritis. Arthrit.Rheumat. 41 1639.

Broadhurst et al (1997) Design and synthesis of the cartilage protective agent (CPA, Ro32-3555). Bioorg.Med.Chem.Letts. 7 2299.

Lewis et al (1997) Ro 32-3555, an orally active collagenase inhibitor, prevents cartilage breakdown in vitro and in vivo. Br.J.Pharmacol. 121 540. PMID: 9179398.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Ro 32-3555 include:

Przybyla et al (2013) Matrix remodeling maintains embryonic stem cell self-renewal by activating Stat3. Stem Cells 31 1097. PMID: 23404867.

Do you know of a great paper that uses Ro 32-3555 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Ro 32-3555, supplier, Ro32-3555, MMP, matrix, metalloproteinase, metalloprotease, collagenase, potent, specific, selective, MMP-1, MMP-13, MMP-8, proteases, proteineases, Tocris Bioscience, Matrix Metalloprotease Inhibitor products

Quick Order

Find multiple products by catalog number

divider line

Neurodegeneration Research Product Guide

Neurodegeneration Product Guide

Our Neurodegeneration guide highlights over 275 products for neurodegeneration research. Request copy or view PDF today.

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

VEGF Pathway & Anti-Angiogenic Therapy

Written by N. Ferrara & Y. Crawford

Angiogenesis Life Science Poster

A summary of antiangiogenic therapies targeting the VEGF pathway and the mechanisms of therapy resistance. Request copy today.

divider line

New Products in this Area

TMI 1

Adam 17 (TACE) and MMP inhibitor; orally bioavailable

Ritonavir

HIV-1 and HIV-2 protease inhibitor

Acetyl Pepstatin

High affinity aspartic protease inhibitor; inhibits HIV-1/2 proteinases

ONO 6818

High affinity and selective human neutraphil elastase 1 (HNE1) inhibitor; orally active

TM 5275 sodium salt

Plasminogen activator inhibitor-1 (PAI-1) inhibitor; orally bioavailable

Sacubitril calcium

Membrane metallo-endopeptidase (neprilysin) inhibitor prodrug; orally bioavailable

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.