EO 1428

Cat. No. 2908

EO 1428 C20H16BrClN2O [321351-00-2]

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Chemical Name: (2-Methylphenyl)-[4-[(2-amino-4-bromophenyl)amino]-2-chlorophenyl]methanone

Biological Activity

Selective inhibitor of p38α and p38β2 that displays no activity at p38γ, p38δ, ERK1/2 and JNK1. Inhibits production of inflammatory cytokines including IL-8, TNF-α, IL-6, IL-1β and IL-10 (IC50 values are 4, 5, 17, 30 and 74 nM respectively). Displays anti-inflammatory activity in murine models of acute and chronic dermatitis.

Technical Data

M.Wt:
415.71
Formula:
C20H16BrClN2O
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
321351-00-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Ottosen et al (2003) Synthesis and structure-activity relationship of aminobenzophenones. A novel class of p38 MAP kinase inhibitors with high antiinflammatory activity. J.Med.Chem. 46 5651. PMID: 14667219.

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Keywords: EO 1428, supplier, Selective, inhibitors, inhibits, p38α, p38alpha, p38β2, p38β, p38beta2, MAPK, Signaling, Signalling, Mitogen-Activated, Protein, Kinases, EO1428, Tocris Bioscience, p38 MAPK Inhibitor products

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