TRO 19622

Cat. No. 2906

TRO 19622 C27H45NO [22033-87-0]

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Alternative Name: Olesoxime

Chemical Name: Cholest-4-en-3-one oxime

Biological Activity

Neuroprotective and neuroregenerative compound. Rescues motor neurons from axotomy-induced cell death and promotes nerve regeneration following sciatic nerve crush in vivo. Binds directly to two components of the mitochondrial permeability pore, the voltage-dependent anion channel (VDAC) and translocator protein; thought to inhibit MPTP opening.

Technical Data

Soluble to 50 mM in DMSO and to 20 mM in ethanol
>98 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Bordet et al (2007) Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis. J.Pharmacol.Exp.Ther. 322 709. PMID: 17496168.

If you know of a relevant reference for TRO 19622 please let us know.

Citations are publications that use Tocris products. Selected citations for TRO 19622 include:

González et al (2016) Blocking mitochondrial calcium release in Schwann cells prevents demyelinating neuropathies. Front Neurosci 126 1023. PMID: 26878172.

Skals et al (2014) Bacterial RTX toxins allow acute ATP release from human erythrocytes directly through the toxin pore. J Biol Chem 289 19098. PMID: 24860098.

Do you know of a great paper that uses TRO 19622 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: TRO 19622, supplier, Neuroprotective, neuroregenerative, Binds, voltage-dependent, anion, VDAC, Channels, modulators, Other, TRO19622, mitochondrial, pore, MPTP, olesoxime, spinal, muscular, atrophy, SMA, Tocris Bioscience, Other Channel Modulator products

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