Ritanserin

Cat. No. 1955

Ritanserin C27H25F2N3OS [87051-43-2]

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Chemical Name: 6-[2-[4-[Bis(4-fluorophenyl)methylene]-1-piperidinyl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one

Biological Activity

Potent and long-acting 5-HT2 receptor antagonist (Ki = 0.39 nM). Anxiolytic in vivo.

Technical Data

M.Wt:
477.57
Formula:
C27H25F2N3OS
Solubility:
Soluble to 25 mM in ethanol and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
87051-43-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Watanabe et al (1992) Syntheses and 5-HT2 antagonist activity of bicyclic 1,2,4-triazol-3(2H)-one and 1,3,5-triazine-2,4(3H)-dione derivatives. J.Med.Chem. 35 189. PMID: 1732528.

Janssen (1985) Pharmacology of potent and selective S2-serotonergic antagonists. J.Cardiovasc.Pharmacol. 7 S2. PMID: 2412048.

Leysen et al (1985) Receptor-binding properties in vitro and in vivo of ritanserin. Mol.Pharmacol. 27 600. PMID: 2860558.

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Citations are publications that use Tocris products. Selected citations for Ritanserin include:

Jahchan et al (2013) A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors. Cancer Discov 3 1364. PMID: 24078773.

Mondal et al (2013) Mechanism of ghrelin-induced gastric contractions in Suncus murinus (house musk shrew): involvement of intrinsic primary afferent neurons. PLoS One 8 e60365. PMID: 23565235.

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Keywords: Ritanserin, supplier, Potent, 5-HT2, antagonists, Non-Selective, Serotonin, Receptors, Tocris Bioscience, Non-selective 5-HT2 Antagonist products

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