Raloxifene hydrochloride

Cat. No. 2280

Raloxifene hydrochloride C28H27NO4S.HCl [82640-04-8]

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Alternative Names: LY 139481, Keoxifene

Chemical Name: [6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone hydrochloride

Biological Activity

Selective estrogen receptor modulator (SERM) that binds to ERα and ERβ, and tissue-dependently activates or blocks estrogen-induced transcription. Acts as an antiestrogen in breast and uterine tissue, but displays estrogen agonist activity in bone. In D12 rat hypothalamic cells, inhibits progesterone receptor induction by estrogen with an IC50 of 1 nM.

Technical Data

M.Wt:
510.04
Formula:
C28H27NO4S.HCl
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
82640-04-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Todorova (2011) Tamoxifen and raloxifene suppress the proliferation of estrogen receptor-negative cells through inhibition of glutamine uptake. Cancer Chemother. Pharmacol. 67 285. PMID: 20383709.

Hibner et al (2004) Effects of raloxifene hydrochloride on endometrial cancer cells in vitro. Gynecologic Oncol. 93 642.

Bryant (2001) Mechanism of action and preclinical profile of raloxifene, a selective estrogen receptor modulator. Rev.Endocr.Metab.Disord. 2 129. PMID: 11704975.

Fitzpatrick et al (1999) Effect of estrogen agonists and antagonists on induction of progesterone receptor in a rat hypothalamic cell line. Endocrinology 140 3928. PMID: 10465261.

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Keywords: Raloxifene hydrochloride, supplier, Selective, estrogen, receptor, modulators, SERM, ER, Estrogen, Receptors, LY139481, amino, acid, transporter, 2, ASCT2, Tocris Bioscience, Estrogen and Related Receptor Modulator products

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