Cat. No. 2280
Alternative Names: LY 139481, Keoxifene
Chemical Name: [6-Hydroxy-2-(4-hydroxyphenyl)benzo
Biological ActivitySelective estrogen receptor modulator (SERM) that binds to ERα and ERβ, and tissue-dependently activates or blocks estrogen-induced transcription. Acts as an antiestrogen in breast and uterine tissue, but displays estrogen agonist activity in bone. In D12 rat hypothalamic cells, inhibits progesterone receptor induction by estrogen with an IC50 of 1 nM.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Todorova (2011) Tamoxifen and raloxifene suppress the proliferation of estrogen receptor-negative cells through inhibition of glutamine uptake. Cancer Chemother. Pharmacol. 67 285. PMID: 20383709.
Hibner et al (2004) Effects of raloxifene hydrochloride on endometrial cancer cells in vitro. Gynecologic Oncol. 93 642.
Bryant (2001) Mechanism of action and preclinical profile of raloxifene, a selective estrogen receptor modulator. Rev.Endocr.Metab.Disord. 2 129. PMID: 11704975.
Fitzpatrick et al (1999) Effect of estrogen agonists and antagonists on induction of progesterone receptor in a rat hypothalamic cell line. Endocrinology 140 3928. PMID: 10465261.
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Citations are publications that use Tocris products. Selected citations for Raloxifene hydrochloride include:
Nicholson et al (2015) Estrogen receptor-α is a key mediator and therapeutic target for bladder complications of benign prostatic hyperplasia. Am J Physiol Heart Circ Physiol 193 722. PMID: 25167991.
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Keywords: Raloxifene hydrochloride, supplier, Selective, estrogen, receptor, modulators, SERM, ER, Estrogen, Receptors, LY139481, amino, acid, transporter, 2, ASCT2, Tocris Bioscience, Estrogen and Related Receptor Modulator products
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