Cat. No. 2905
Chemical Name: 6,7-Dihydro-3-[(2-hydroxyethyl)thio
Biological ActivityGABAA receptor inverse agonist selective for the α5-subtype (Ki values are 1.6, 16, 20 and 20 nM for α5, α2, α1 and α3 subtypes respectively). Brain penetrant; enhances cognitive performance in rats in the delayed matching-to-place morris water maze test following i.p. administration.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Chambers et al (2003) Identification of a novel, selective GABA5 α5 receptor inverse agonist which enhances cognition. J.Med.Chem. 46 2227. PMID: 12747794.
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Citations are publications that use Tocris products. Selected citations for TB 21007 include:
Koh et al (2013) Selective GABA(A) α5 positive allosteric modulators improve cognitive function in aged rats with memory impairment. J Clin Invest 64 145. PMID: 22732440.
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Keywords: TB 21007, supplier, α5, alpha5-selective, GABAA, inverse, agonists, Receptors, TB21007, Tocris Bioscience, GABAA Receptor Antagonist products
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