MRS 1754

Cat. No. 2752

MRS 1754 C26H26N6O4 [264622-58-4]

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Chemical Name: N-(4-Cyanophenyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-acetamide

Biological Activity

Selective adenosine A2B receptor antagonist (Ki values are 1.97, 16.8, 403, 503, 570 and 612 nM for hA2B, rA1, hA1, hA2A, hA3 and rA2A receptors respectively).

Licensing Information

Sold with the permission of the University of Virginia Patent Foundation

Technical Data

M.Wt:
486.52
Formula:
C26H26N6O4
Solubility:
Soluble to 5 mM in DMSO with gentle warming and to 10 mM in DMSO with sonication
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
264622-58-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Nemeth et al (2007) Adenosine receptor activation ameliorates type I diabetes. FASEB J. 21 2380.

Ji et al (2001) [3H]MRS 1754, a selective antagonist radioligand for A2B adenosine receptors. Biochem.Pharmacol. 61 657. PMID: 11266650.

Kim et al (2000) Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A2B adenosine receptors. J.Med.Chem. 43 1165. PMID: 10737749.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for MRS 1754 include:

Welihinda and Amento (2014) Positive allosteric modulation of the adenosine A2a receptor attenuates inflammation. J Inflamm (Lond) 11 37. PMID: 25473378.

He et al (2013) Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma. FASEB J 27 3446. PMID: 23682121.

Kan et al (2012) Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway. J Virol 86 10338. PMID: 22787201.

Hua et al (2011) IL-4 amplifies the pro-inflammatory effect of adenosine in human mast cells by changing expression levels of adenosine receptors. PLoS One 6 e24947. PMID: 21966389.

Gebremedhin et al (2010) Adenosine can mediate its actions through generation of reactive oxygen species. J Cereb Blood Flow Metab 30 1777. PMID: 20531463.

Do you know of a great paper that uses MRS 1754 from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: MRS 1754, supplier, Selective, A2B, antagonists, Receptors, adenosines, MRS1754, Tocris Bioscience, A2B Receptor Antagonist products

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