Cat. No. 1682
Alternative Name: 2,2'-Pyridylisatogen tosylate
Chemical Name: 2-(2-Pyridinyl)-(3H)-indol-3-one-1-
Biological ActivityPurinergic P2Y receptor ligand. Displays irreversible antagonism at P2Y receptors in some smooth muscles but potentiates responses to ATP in other systems (chick brain recombinant P2Y1 receptor and sympathetic/purinergic nerve stimulation).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Ren and Burnstock (1997) Prominent sympathetic purinergic vasoconstriction in the rabbit splenic artery: potentiation by 2.2'-pyridylisatogen tosylate. Br.J.Pharmacol. 120 530. PMID: 9031760.
King et al (1996) Potentiation by 2,2'-pyridylisatogen tosylate of ATP-responses at a recombinant P2Y1 purinoceptor. Br.J.Pharmacol. 117 1111. PMID: 8882604.
Spedding et al (1975) Antagonism of adenosine 5'-triphosphate-induced relaxation by 2-2'-pyridylisatogen in the taenia of guinea-pig caecum. Br.J.Pharmacol. 53 575. PMID: 1148500.
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Keywords: PIT, supplier, P2Y, ligands, displays, mixed, antagonism/potentiation, Receptors, Purinergic, antagonists, potentiators, purinoceptors, Tocris Bioscience, Purinergic (P2Y) Receptor products
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