Cat. No. 1682
Alternative Name: 2,2'-Pyridylisatogen tosylate
Chemical Name: 2-(2-Pyridinyl)-(3H)-indol-3-one-1-
Biological ActivityPurinergic P2Y receptor ligand. Displays irreversible antagonism at P2Y receptors in some smooth muscles but potentiates responses to ATP in other systems (chick brain recombinant P2Y1 receptor and sympathetic/purinergic nerve stimulation).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Ren and Burnstock (1997) Prominent sympathetic purinergic vasoconstriction in the rabbit splenic artery: potentiation by 2.2'-pyridylisatogen tosylate. Br.J.Pharmacol. 120 530. PMID: 9031760.
King et al (1996) Potentiation by 2,2'-pyridylisatogen tosylate of ATP-responses at a recombinant P2Y1 purinoceptor. Br.J.Pharmacol. 117 1111. PMID: 8882604.
Spedding et al (1975) Antagonism of adenosine 5'-triphosphate-induced relaxation by 2-2'-pyridylisatogen in the taenia of guinea-pig caecum. Br.J.Pharmacol. 53 575. PMID: 1148500.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses PIT from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: PIT, supplier, P2Y, ligands, displays, mixed, antagonism/potentiation, Receptors, Purinergic, antagonists, potentiators, purinoceptors, Tocris Bioscience, Purinergic (P2Y) Receptor products
Find multiple products by catalog number
New Products in this Area
Potent free fatty acid receptor 1 (FFA1/GPR40) partial agonistUMB 68
GHB receptor ligandAZD 1283
High affinity P2Y12 antagonistEx 26
Potent and selective S1P1 receptor antagonistZQ 16
Selective GPR84 agonistIHR-Cy3
Potent fluorescent Smo antagonistRo 6842262
Potent LPA1 antagonistAMG 853
Potent dual CRTH2 and prostaglandin D2 (PGD2) receptor antagonistAM 4668
Potent FFA1 (GPR40) agonistCATPB
FFA2 antagonist/inverse agonistOleanolic acid
Selective GPBA receptor (TGR5) partial agonist
March 18 - 22, 2017
Little Rock, ARK, USA