Cat. No. 2891
Alternative Name: GR 38032
Chemical Name: 1,2,3,9-Tetrahydro-9-methyl-3-[(2-m
Biological ActivitySelective 5-HT3 receptor antagonist (Ki = 6.16 nM). Antiemetic; prevents emesis induced by cytotoxic drugs and radiation.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Ginawi et al (2005) Ondansetron, a selective antagonist, antagonizes methamphetamine-induced anorexia in mice. Pharmacol.Res. 51 255. PMID: 15661576.
Ye et al (2001) Ondansetron: a selective 5-HT3 receptor antagonist and its applications in CNS-related disorders. CNS Drug Rev. 7 199. PMID: 11474424.
Youssefyeh et al (1992) Development of high-affinity 5-HT3 receptor antagonists. 1. Initial structure-activity relationship of novel benzamides. J.Med.Chem. 35 895. PMID: 1312602.
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Citations are publications that use Tocris products. Selected citations for Ondansetron hydrochloride include:
Pezeshki et al (2016) Low protein diets produce divergent effects on energy balance. PLoS One 6 25145. PMID: 27122299.
Amorim et al (2015) Galanin-Mediated Behavioural Hyperalgesia from the Dorsomedial Nucleus of the Hypothalamus Involves Two Independent Descending Pronociceptive Pathways. Antioxid Redox Signal 10 e0142919. PMID: 26565961.
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Keywords: Ondansetron hydrochloride, supplier, Selective, 5-HT3, antagonists, Serotonin, Receptors, GR38032, Tocris Bioscience, 5-HT3 Receptor Antagonist products
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