Ondansetron hydrochloride

Cat. No. 2891

Ondansetron hydrochloride C18H19N3O.HCl [99614-01-4]

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Alternative Name: GR 38032

Chemical Name: 1,2,3,9-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one hydrochloride

Biological Activity

Selective 5-HT3 receptor antagonist (Ki = 6.16 nM). Antiemetic; prevents emesis induced by cytotoxic drugs and radiation.

Technical Data

M.Wt:
329.83
Formula:
C18H19N3O.HCl
Solubility:
Soluble to 50 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
99614-01-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Ginawi et al (2005) Ondansetron, a selective antagonist, antagonizes methamphetamine-induced anorexia in mice. Pharmacol.Res. 51 255. PMID: 15661576.

Ye et al (2001) Ondansetron: a selective 5-HT3 receptor antagonist and its applications in CNS-related disorders. CNS Drug Rev. 7 199. PMID: 11474424.

Youssefyeh et al (1992) Development of high-affinity 5-HT3 receptor antagonists. 1. Initial structure-activity relationship of novel benzamides. J.Med.Chem. 35 895. PMID: 1312602.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Ondansetron hydrochloride include:

Pezeshki et al (2016) Low protein diets produce divergent effects on energy balance. PLoS One 6 25145. PMID: 27122299.

Amorim et al (2015) Galanin-Mediated Behavioural Hyperalgesia from the Dorsomedial Nucleus of the Hypothalamus Involves Two Independent Descending Pronociceptive Pathways. Antioxid Redox Signal 10 e0142919. PMID: 26565961.

Do you know of a great paper that uses Ondansetron hydrochloride from Tocris? If so please let us know.

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Keywords: Ondansetron hydrochloride, supplier, Selective, 5-HT3, antagonists, Serotonin, Receptors, GR38032, Tocris Bioscience, 5-HT3 Receptor Antagonist products

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Written by N. Barnes & J. Neumaler

5-HT Receptors Scientific Review

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