NKH 477

Cat. No. 1603

NKH 477 C27H43NO8.HCl [138605-00-2]

Price and Availability

For NKH 477 pricing & availability please select your country from the drop down menu:
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Alternative Names: Colforsin dapropate hydrochloride, 6-(3-dimethylaminopropionyl)forskolin hydrochloride

Chemical Name: N,N-Dimethyl-(3R,4aR,5S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester β-alanine hydrochloride

Biological Activity

Water-soluble analog of forskolin (Cat. No. 1099) that is a potent activator of adenylyl cyclase; shows some selectivity for cardiac (type V) adenylyl cyclase. Stimulates bronchodilation (EC50 = 32.6 nM) and is an orally active potent positive chronotrope and hypotensive agent in vivo. Also available as part of the PKA Tocriset™.

Technical Data

Soluble to 40 mM in water
>98 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
Select another batch:

References are publications that support the products' biological activity.

Satake et al (1998) Relaxant effects of NKH477, a new water-soluble forskolin derivative, on guinea-pig tracheal smooth muscle: the role of Ca2+-activated K+ channels. Br.J.Pharmacol. 123 753. PMID: 9517396.

Toya et al (1998) Forskolin derivatives with increased selectivity for cardiac adenylyl cyclase. J.Mol.Cell.Cardiol. 30 97. PMID: 9500868.

Hosono et al (1992) Cardiovascular and adenylate cyclase stimulant properties of NKH477, a novel water-soluble forskolin derivative. J.Cardiovasc.Pharmacol. 19 625. PMID: 1380607.

If you know of a relevant reference for NKH 477 please let us know.

Citations are publications that use Tocris products. Selected citations for NKH 477 include:

Muschter et al (2015) Sympathetic Neurotransmitters Modulate Osteoclastogenesis and Osteoclast Activity in the Context of Collagen-Induced Arthritis. PLoS One 10 e0139726. PMID: 26431344.

Brosnahan et al (2013) Norepinephrine potentiates proinflammatory responses of human vaginal epithelial cells. Cell Mol Neurobiol 259 42583. PMID: 23571017.

Lee et al (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature 492 123. PMID: 23143333.

Xia et al (2011) Inhibition of morphine-induced cAMP overshoot: a cell-based assay model in a high-throughput format. PLoS One 31 901. PMID: 21598037.

Do you know of a great paper that uses NKH 477 from Tocris? If so please let us know.show all ▼show less ▲

View Related Products by Product Action

Keywords: NKH 477, supplier, Water-soluble, adenylyl, adenylate, cyclases, activators, cAMP, NKH477, Tocris Bioscience, Adenylyl Cyclase Activator products

Quick Order

Find multiple products by catalog number

divider line

Schizophrenia Life Science Poster

Written by J. Lieberman

Schizophrenia Life Science Poster

Our Schizophrenia poster higlights the targets and pathways representing the most promising strategies to pursue for novel drug development. Request copy today.

divider line

New Products in this Area

ST 034307

Adenylyl cyclase 1 (AC1) inhibitor; analgesic and active in vivo

Sign-up for new product e-alerts
divider line

Neuroscience 2017

Win a $1,000 travel grant

Neuroscience 2017 Travel grant

Bio-Techne is offering 10 travel grants of $1,000 for Neuroscience 2017.