Cat. No. 2851
Alternative Name: DM 9384
Chemical Name: N-(2,6-Dimethylphenyl)-2-oxo-1-pyrr
Biological ActivityCognitive enhancer that displays various pharmacological effects. Activates L/N-type calcium channels, cholinergic, monoaminergic and GABAergic systems. Displays potent neuroprotective action in the retinal ischemia-reperfusion model in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kitano et al (2005) Effects of nefiracetam, a novel pyrrolidone-type nootropic agent, on the amygdala-kindled seizures in rats. Epilepsia 46 1561. PMID: 16190926.
Narahashi et al (2004) Mechanisms of action of cognitive enhancers on neuroreceptors. Biol.Pharm.Bull. 27 1701. PMID: 15516710.
Ueda et al (2004) The cognitive-enhancer nefiracetam inhibits both necrosis and apoptosis in retinal ischemic models in vitro and in vivo. J.Pharmacol.Exp.Ther. 309 200. PMID: 14718588.
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Keywords: Nefiracetam, supplier, Cognitive, enhancer, activates, L/N-type, Ca2+, channels, potentiates, NMDA, currents, Muscarinic, Receptors, Acetylcholine, Nicotinic, nAChR, Calcium, CaV, Channels, L-Type, N-Type, voltage-gated, voltage-dependent, Glutamate, N-Methyl-D-Aspartate, iGluR, Ionotropic, DM9384, Tocris Bioscience, Other Acetylcholine products