B2

Cat. No. 2855

B2 C20H17ClN4O3 [115687-05-3]

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Alternative Name: CPNQ

Chemical Name: 5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline

Biological Activity

Promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease. Prevents mutant huntingtin-mediated proteasome dysfunction and reduces α-synuclein-mediated toxicity.

Technical Data

M.Wt:
396.83
Formula:
C20H17ClN4O3
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
115687-05-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Bodner et al (2006) Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parksinson's diseases. Proc.Natl.Acad.Sci.USA 103 4246.

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Citations are publications that use Tocris products.

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Keywords: B2, supplier, Promotes, inclusion, formation, Huntingtons, Parkinsons, parkinson's, diseases, Huntingdons, Neuronal, Metabolism, Huntington's, Tocris Bioscience, Neuronal Metabolism products

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