Luteolin

Cat. No. 2874

Luteolin C15H10O6 [491-70-3]

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Alternative Name: 3',4',5,7-Tetrahydroxyflavone

Chemical Name: 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one

Biological Activity

Anti-inflammatory, antioxidant and free radical scavenger. Inhibits LPS-induced TNF-α, IL-6 and inducible nitric oxide production and blocks NF-κB and AP-1 activation. Also inhibits TNF-α -induced COX-2 expression. Antiproliferative and chemopreventative; inhibits proliferation of Lewis lung carcinoma cells in vivo.

Technical Data

M.Wt:
286.24
Formula:
C15H10O6
Solubility:
Soluble to 5 mM in 1eq. NaOH and to 50 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
491-70-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Kim et al (2011) Luteolin, a novel natural inhibitor of tumor progression locus 2 serine/ threonine kinase, inhibits tumor necrosis factor-α-induced cyclooxygenase-2 expression in JB6 mouse epidermis cells. J.Pharm.Exp.Ther. 338 1013.

Chen et al (2007) Luteolin suppresses inflammation-associated gene expression by blocking NF-κB and AP-1 activation pathway in mouse alveolar macrophage. Life Sci. 81 1602. PMID: 17977562.

Ju et al (2007) A critical role of luteolin-induced reactive oxygen species in blockage of tumour necrosis factor-activated nuclear factor-κB pathway and sensitization of apoptosis in lung cancer cells. Mol.Pharmacol. 71 1381. PMID: 17296806.

Kim et al (2007) Caspase activation and extracellular signal-regulated kinase/Akt inhibition were involved in luteolin-induced apoptosis in Lewis lung carcinoma cells. Ann.N.Y.Acad.Sci. 1090 597.

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Keywords: Luteolin, supplier, Anti-inflammatory, antioxidant, free, radical, scavengers, NF-kB, NF-kappaB, NF-κB, inhibitors, inhibits, blocks, activation, Tocris Bioscience, Antioxidant products

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