Leuprolide

Cat. No. 2873

Leuprolide Glp-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt

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Alternative Name: Leuoprorelin

Biological Activity

Gonadotropin-releasing hormone (GnRH, luteinizing hormone-releasing hormone, LHRH) receptor agonist. Suppresses estradiol, LH and FSH serum levels and represses the growth of experimental rat endometriosis.

Technical Data

M.Wt:
1209.41
Formula:
C59H84N16O12
Sequence:
XHWSYLLRP

(Modifications: X1 = Glp, Pro-9 = Pro-NHEt)

Solubility:
Soluble to 0.50 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
53714-56-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Uday et al (2007) LHRH antagonist attenuates the effect of fluoxetine on marble-burying behavior in mice. Eur.J.Pharmacol. 563 155. PMID: 17368614.

Salvador et al (2001) Effects of the luteinising hormone-releasing hormone (LH-RH) agonist leuprolide on adenylyl cyclase regulation through G-protein coupled receptors in rat ventral prostate. Eur.J.Pharmacol. 37 641.

Okada et al (1988) One-month release injectable microcapsules of a luteinizing hormone-releasing hormone agonist (leuprolide acetate) for treating experimental endometriosis in rats. J.Pharmacol.Exp.Ther. 244 744. PMID: 3126294.

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Keywords: Leuprolide, supplier, GnRH, receptor, agonists, Receptors, Gonadotrophin-Releasing, Hormone, gonadotropin, chemotherapeutics, Tocris Bioscience, Gonadotropin-Releasing Hormone Receptor Agonist products

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