Cat. No. 2864
Chemical Name: N,N-Dimethylimidodicarbonimidic diamide hydrochloride
Biological ActivityAntidiabetic agent; lowers plasma glucose levels and improves insulin sensitivity. Inhibits hepatic gluconeogenesis via activation of the LKB1/AMPK pathway. Displays antiproliferative effects in cancer cell lines. Activates the aPKC-CBP pathway in neural precursors to promote neurogenesis. Activates autophagy.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov.. PMID: 28529316 .
Hirsch et al (2013) Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth. Proc.Natl.Acad.Sci.USA 110 972. PMID: 23277563.
Wang et al (2012) Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation. Cell Stem Cell 11 23. PMID: 22770240.
Towler and Hardie (2007) AMP-activated protein kinase in metabolic control and insulin signalling. Circ.Res. 100 328. PMID: 17307971.
Shaw et al (2005) The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310 1642. PMID: 16308421.
If you know of a relevant reference for Metformin hydrochloride please let us know.
Citations are publications that use Tocris products. Selected citations for Metformin hydrochloride include:
Lin et al (2015) Development of telmisartan in the therapy of spinal cord injury: pre-clinical study in rats. Nat Commun 9 4709. PMID: 26316709.
Mo et al (2015) Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. Nat Cell Biol 17 500. PMID: 25751140.
Naka et al (2015) Dipeptide species regulate p38MAPK-Smad3 signalling to maintain chronic myelogenous leukaemia stem cells. BMC Cancer 6 8039. PMID: 26289811.
Yan et al (2015) Suppression of experimental arthritis through AMP-activated protein kinase activation and autophagy modulation. J Rheum Dis Treat 1 5. PMID: 26120598.
Yung et al (2013) Activation of AMPK inhibits cervical cancer cell growth through AKT/FOXO3a/FOXM1 signaling cascade. PLoS One 13 327. PMID: 23819460.
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Keywords: Metformin hydrochloride, supplier, activators, LKB1/AMPK, antidiabetic, agent, AMP-Activated, Protein, Kinases, Enzyme, Substrates, Tocris Bioscience, AMPK Activator products
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