Cat. No. 2837
Biological ActivityMember of the neurotrophin growth factor family that binds and activates TrkB and p75 neurotrophin receptors. Enhances the survival, growth and differentiation of neurons. BDNF expression is altered in neurodegenerative disorders such as Parkinson's and Alzheimer's disease.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Evans and Barker (2008) Neurotrophic factors as a therapeutic target for Parkinson's disease. Expert Opin.Ther.Targets 12 437. PMID: 18348680.
Wang et al (2008) The when and where of BDNF and the antidepressant response. Biol.Psychiat. 63 640.
Lipsky and Marini (2007) Brain-derived neurotrophic factor in neuronal survival and behavior-related plasticity. Ann.N.Y.Acad.Sci. 1122 130. PMID: 18077569.
If you know of a relevant reference for BDNF (human) please let us know.
Citations are publications that use Tocris products. Selected citations for BDNF (human) include:
Zhong et al (2015) BDNF interacts with endocannabinoids to regulate cocaine-induced synaptic plasticity in mouse midbrain dopamine neurons. Mol Pain 35 4469. PMID: 25762688.
Parsons et al (2014) Bidirectional control of postsynaptic density-95 (PSD-95) clustering by Huntingtin. J Biol Chem 289 3518. PMID: 24347167.
Hossaini et al (2010) Nociceptive stimulation induces expression of Arc/Arg3.1 in the spinal cord with a preference for neurons containing enkephalin. Cell Metab 6 43. PMID: 20653942.
Do you know of a great paper that uses BDNF (human) from Tocris? If so please let us know.
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Keywords: BDNF (human), supplier, activators, TrkB, p75, receptors, Neurotrophin, Receptors, Receptor, Tyrosine, Kinases, RTKs, Tocris Bioscience, Trk Receptor Agonist products
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