DFMO

Cat. No. 2761

DFMO C6H12F2N2O2.HCl [68278-23-9]

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Alternative Name: Eflornithine

Chemical Name: DL-2-(Difluoromethyl)-ornithine hydrochloride

Biological Activity

Irreversible inhibitor of ornithine decarboxylase (ODC) that inhibits polyamine biosynthesis. Displays antiapoptotic, antiangiogenic and antiparasitic activity. Induces re-expression of aberrantly silenced tumor suppressor genes when used in combination with oligoamine analogs.

Technical Data

M.Wt:
218.63
Formula:
C6H12F2N2O2.HCl
Solubility:
Soluble to 75 mM in water
Storage:
Desiccate at RT
CAS No:
68278-23-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Wu et al (2012) Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes. Biochem.J. 442 693. PMID: 22132744.

Raul (2007) Revival of 2-(difluoromethyl)ornithine (DFMO), an inhibitor of polyamine biosynthesis, as a cancer chemopreventative agent. Biochem.Soc.Trans. 35 353. PMID: 17371277.

Carrillo et al (2000) Sensitivity of Trypanosomatid protozoa to DFMO and metabolic turnover of ornithine decarboxylase. Biochem.Biophys.Res.Comm. 279 663.

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Keywords: DFMO, supplier, Ornithine, decarboxylases, inhibitors, inhibits, Tocris Bioscience, Decarboxylase Inhibitor products

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