Cat. No. 2761
Alternative Name: Eflornithine
Chemical Name: DL-2-(Difluoromethyl)-ornithine hydrochloride
Biological ActivityIrreversible inhibitor of ornithine decarboxylase (ODC) that inhibits polyamine biosynthesis. Displays antiapoptotic, antiangiogenic and antiparasitic activity. Induces re-expression of aberrantly silenced tumor suppressor genes when used in combination with oligoamine analogs.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Wu et al (2012) Oligoamine analogues in combination with 2-difluoromethylornithine synergistically induce re-expression of aberrantly silenced tumour-suppressor genes. Biochem.J. 442 693. PMID: 22132744.
Raul (2007) Revival of 2-(difluoromethyl)ornithine (DFMO), an inhibitor of polyamine biosynthesis, as a cancer chemopreventative agent. Biochem.Soc.Trans. 35 353. PMID: 17371277.
Carrillo et al (2000) Sensitivity of Trypanosomatid protozoa to DFMO and metabolic turnover of ornithine decarboxylase. Biochem.Biophys.Res.Comm. 279 663.
If you know of a relevant reference for DFMO please let us know.
Citations are publications that use Tocris products.
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Keywords: DFMO, supplier, Ornithine, decarboxylases, inhibitors, inhibits, Tocris Bioscience, Decarboxylase Inhibitor products
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