Caffeic acid phenethyl ester

Cat. No. 2743

Caffeic acid phenethyl ester C17H16O4 [104594-70-9]

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Alternative Name: CAPE

Chemical Name: 3-(3,4-Dihydroxyphenyl)-2-propenoic acid 2-phenylethyl ester

Biological Activity

Antioxidant, antimitogenic, anticarcinogenic, anti-inflammatory and antiviral. Specifically inhibits NF-κB activation and inhibits the growth of transformed cells. Also suppresses lipid peroxidation and inhibits ornithine decarboxylase, protein tyrosine kinase and lipoxygenase activities.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
>99 %
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
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Safety Data Sheet: View Safety Data Sheet

Fitzpatrick et al (2001) Caffeic acid phenethyl ester, an inhibitor of nuclear factor-κB, attenuates bacterial peptidoglycan polysaccharide-induced colitis in rats. J.Pharmacol.Exp.Ther. 299 915. PMID: 11714876.

Natarajan et al (1996) Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-κB. Proc.Natl.Acad.Sci.USA 93 9090.

Sud'ina et al (1993) Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties. FEBS Lett. 329 21. PMID: 7689063.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Caffeic acid phenethyl ester include:

Mia and Bank (2016) The pro-fibrotic properties of transforming growth factor on human fibroblasts are counteracted by caffeic acid by inhibiting myofibroblast formation and collagen synthesis. PLoS Pathog 363 775. PMID: 26453399.

Brosig et al (2015) Gene expression regulation in retinal pigment epithelial cells induced by viral RNA and viral/bacterial DNA. Mol Vis 21 1000. PMID: 26330750.

Hollborn et al (2015) Regulation of the hyperosmotic induction of aquaporin 5 and VEGF in retinal pigment epithelial cells: involvement of NFAT5. Cell Biosci 21 360. PMID: 25878490.

Munegowda and Hu (2015) Transient blocking of NK cell function with small molecule inhibitors for helper dependant adenoviral vector-mediated gene delivery. J Exp Clin Cancer Res 5 29. PMID: 26085921.

Ong et al (2015) Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis. Mol Vis 11 e1004917. PMID: 25996154.

Pysz et al (2014) Differential regulation of cyclin D1 expression by protein kinase C α and ε signaling in intestinal epithelial cells. J Biol Chem 289 22268. PMID: 24914206.

Zhu et al (2012) BlyS is up-regulated by hypoxia and promotes migration of human breast cancer cells. Front Cell Neurosci 31 31. PMID: 22463935.

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Keywords: Caffeic acid phenethyl ester, supplier, Specific, inhibitors, inhibits, NF-κB, NF-kappaB, NF-kB, activation, Transcription, Factors, Nuclear, Factor, Kappa, B, Cytokine, Signaling, Signalling, Tocris Bioscience, NF-κB and IκB Inhibitor products

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