Cat. No. 2735
Chemical Name: 1-[2-(3,4-Dihydro-1H-2-benzopyran-1
Biological ActivityAntipsychotic agent. Displays high affinity for dopamine D4 and serotonergic 5-HT2A receptors and relatively weak affinity at D2 receptors (Ki values are 3.0, 5.8, 134, 181, 199, 240, 411 and > 678 nM for D4, 5-HT2A, 5-HT1A, α1, D2, D3, D1, α2 and muscarinic receptors respectively). Inhibits exploratory locomotor activity and antagonizes d-amphetamine-induced locomotor stimulation in rats.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
Goudie et al (1998) Discriminative stimulus properties of the atypical neuroleptic clozapine in rats: tests with subtype selective receptor ligands. Behav.Pharmacol. 9 699. PMID: 9890260.
Tang et al (1997) PNU-96415E, a potential antipsychotic agent with clozapine-like pharmacological properties. J.Pharmacol.Exp.Ther. 281 440. PMID: 9103528.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses PNU 96415E from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: PNU 96415E, supplier, 5-HT2A, D4, antagonists, antipsychotic, Serotonin, Receptors, Dopamine, dopaminergic, PNU96415E, Tocris Bioscience, D4 Receptor Antagonist products
Find multiple products by catalog number
New Products in this Area
G protein-biased D2 receptor partial agonist
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.