Biperiden hydrochloride

Cat. No. 2853

Biperiden hydrochloride C21H29NO.HCl [1235-82-1]

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Alternative Name: Akineton

Chemical Name: α-Bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-1-piperidinepropanol hydrochloride

Biological Activity

Muscarinic receptor antagonist that displays some selectivity for the M1 subtype (Ki values are 0.48, 2.4, 3.9, 6.3 and 6.3 nM for M1, M4, M3, M2 and M5 receptors respectively). Alleviates extrapyramidal symptoms associated with antipsychotic drugs. Displays antiparkinsonian activity.

Technical Data

M.Wt:
347.92
Formula:
C21H29NO.HCl
Solubility:
Soluble to 5 mM in water and to 10 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
1235-82-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Brocks (1999) Anticholinergic drugs used in Parkinson's disease: an overlooked class of drugs from a pharmacokinetic perspective. J.Pharm.Pharmaceut.Sci. 2 39.

Sudo et al (1999) Muscarinic receptor occupancy by biperiden in living human brain. Life Sci. 64 PL99. PMID: 10069534.

Bolden et al (1992) Antagonism by antimuscarinic and neuroleptic compounds at the five cloned human muscarinic cholinergic receptors expressed in chinese hamster ovary cells. J.Pharmacol.Exp.Ther. 260 576. PMID: 1346637.

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Keywords: Biperiden hydrochloride, supplier, Muscarinic, receptor, antagonists, selectivity, M1, Receptors, Acetylcholine, ACh, Tocris Bioscience, M1 Receptor Antagonist products

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