Cat. No. 2853
Alternative Name: Akineton
Chemical Name: α-Bicyclo[2.2.1]hept-5-en-2-yl-α-phen
Biological ActivityMuscarinic receptor antagonist that displays some selectivity for the M1 subtype (Ki values are 0.48, 2.4, 3.9, 6.3 and 6.3 nM for M1, M4, M3, M2 and M5 receptors respectively). Alleviates extrapyramidal symptoms associated with antipsychotic drugs. Displays antiparkinsonian activity.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Brocks (1999) Anticholinergic drugs used in Parkinson's disease: an overlooked class of drugs from a pharmacokinetic perspective. J.Pharm.Pharmaceut.Sci. 2 39.
Sudo et al (1999) Muscarinic receptor occupancy by biperiden in living human brain. Life Sci. 64 PL99. PMID: 10069534.
Bolden et al (1992) Antagonism by antimuscarinic and neuroleptic compounds at the five cloned human muscarinic cholinergic receptors expressed in chinese hamster ovary cells. J.Pharmacol.Exp.Ther. 260 576. PMID: 1346637.
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Keywords: Biperiden hydrochloride, supplier, Muscarinic, receptor, antagonists, selectivity, M1, Receptors, Acetylcholine, ACh, Tocris Bioscience, M1 Receptor Antagonist products
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November 8 - 10, 2017