SecinH3

Cat. No. 2849

SecinH3 C24H20N4O4S [853625-60-2]

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Chemical Name: N-[4-[5-(1,3-Benzodioxol-5-yl)-3-methoxy-1H-1,2,4-triazol-1-yl]phenyl]-2-(phenylthio)acetamide

Biological Activity

Sec7-specific GEF inhibitor that displays selectivity for small GEFs of the cytohesin family (IC50 values are 2.4, 5.4, 5.4, 5.6, 5.6, 65 and > 100 μM for hCyh2, hCyh1, mCyh3, hCyh3, drosophila steppke, yGea2-S7 and hEFA6-S7 respectively). Inhibits insulin signaling via inhibition of insulin receptor substrate protein (IRS) phosphorylation.

Technical Data

M.Wt:
460.5
Formula:
C24H20N4O4S
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol with gentle warming
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
853625-60-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Fuss et al (2006) The cytohesin Steppke is essential for insulin signalling in Drosophila. Nature 444 945. PMID: 17167488.

Hafner et al (2006) Inhibition of cytohesins by secinH3 leads to hepatic insulin resistance. Nature 444 941. PMID: 17167487.

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Keywords: SecinH3, supplier, Sec7-specific, GEF, inhibitors, inhibits, cytohesins, hCyh2, hCyh1, mCyh3, hCyh3, drosophila, steppke, G, Proteins, Small, Tocris Bioscience, G Protein (Small) Inhibitor products

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