Mibefradil dihydrochloride

Cat. No. 2198

Mibefradil dihydrochloride C29H38FN3O3.2HCl [116666-63-8]

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Alternative Name: Ro 40-5967

Chemical Name: (1S,2S)-2-[2-[[3-(1H-Benzimidazol-2yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl methoxyacetoacetate dihydrochloride

Biological Activity

Ca2+ channel blocker with moderate selectivity for T-type Ca2+ channels displaying IC50 values of 2.7 μM and 18.6 μM for T-type and L-type channels respectively. Antihypertensive agent.

Technical Data

M.Wt:
568.56
Formula:
C29H38FN3O3.2HCl
Solubility:
Soluble to 50 mM in water and to 100 mM in DMSO
Purity:
>97 %
Storage:
Store at -20°C
CAS No:
116666-63-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Mehrke et al (1994) The Ca(++)-channel blocker Ro 40-5967 blocks differently T-type and L-type Ca++ channels. J.Pharmacol.Exp.Ther. 271 1483. PMID: 7996461.

Veniant et al (1991) Hemodynamic profile of Ro 40-5967 in conscious rats: comparison with diltiazem, verapamil, and amlodipine. J.Cardiovasc.Pharmacol. 18 (Suppl 10 ) S55. PMID: 1725005.

Osterrieder and Holck (1989) In vitro pharmacologic profile of Ro 40-5967, a novel Ca2+ channel blocker with potent vasodilator but weak inotropic action. J.Cardiovasc.Pharmacol. 13 754. PMID: 2472524.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Mibefradil dihydrochloride include:

Prigge et al (2016) M1 ipRGCs Influence Visual Function through Retrograde Signaling in the Retina The Journal of Neuroscience 6 7184. PMID: 27383593.

Wang et al (2015) Hydrogen sulfide-induced itch requires activation of Cav3.2 T-type calcium channel in mice. Nature 5 16768. PMID: 26602811.

Stone et al (2013) Attenuation of autonomic reflexes by A803467 may not be solely caused by blockade of NaV 1.8 channels. Sci Rep 543 177. PMID: 23523647.

Weick and Demb (2011) Delayed-rectifier K channels contribute to contrast adaptation in mammalian retinal ganglion cells. Neuron 71 166. PMID: 21745646.

Grubb and Burrone (2010) Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability. Neurosci Lett 465 1070. PMID: 20543823.

Higley and Sabatini (2010) Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors. Nat Neurosci 13 958. PMID: 20601948.

Do you know of a great paper that uses Mibefradil dihydrochloride from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Mibefradil dihydrochloride, supplier, Ca2+, channel, blockers, T-type, Calcium, CaV, Channels, L-Type, P-Type, R-Type, Q-Type, T-Type, N-Type, voltage-gated, voltage-dependent, Ro405967, Tocris Bioscience, Voltage-gated Calcium Channel (CaV) Blocker products

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