IBMX

Cat. No. 2845

IBMX C10H14N4O2 [28822-58-4]

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Chemical Name: 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione

Biological Activity

Phosphodiesterase inhibitor (IC50 values are 13, 18, 19, 32 and 50 μM for PDE4, PDE3, PDE1, PDE5 and PDE2 respectively). Suppresses α-adrenoceptor-mediated 5-HT release from neuroendocrine epithelial cells (IC50 = 1.3 μM). Facilitates differentiation of neural progenitor cells in vitro.

Technical Data

M.Wt:
222.24
Formula:
C10H14N4O2
Solubility:
Soluble to 75 mM in DMSO and to 50 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
28822-58-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Lepski et al (2013) cAMP promotes the differentiation of neural progenitor cells in vitro via modulation of voltage-gated calcium channels. Front.Cell Neurosci. 7 155. PMID: 24065885.

Freitag et al (1998) Phosphodiesterase inhibitors suppress α2-adrenoceptor-mediated 5-hydroxytryptamine release from tracheae of newborn rabbits. Eur.J.Pharmacol. 354 67. PMID: 9726632.

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Citations are publications that use Tocris products. Selected citations for IBMX include:

Elliott et al (2015) Somatostatin and insulin mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP. Am J Physiol Endocrinol Metab 308 E130. PMID: 25406263.

Cuppoletti et al (2013) Methadone but not morphine inhibits lubiprostone-stimulated Cl- currents in T84 intestinal cells and recombinant human ClC-2, but not CFTR Cl- currents. Cell Biochem Biophys 66 53. PMID: 22918821.

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Keywords: IBMX, supplier, PDE, inhibitors, inhibits, non-selective, Phosphodiesterases, Tocris Bioscience, Phosphodiesterase Inhibitor products

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