IBMX

Cat. No. 2845

IBMX C10H14N4O2 [28822-58-4]

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Chemical Name: 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione

Biological Activity

Phosphodiesterase inhibitor (IC50 values are 13, 18, 19, 32 and 50 μM for PDE4, PDE3, PDE1, PDE5 and PDE2 respectively). Suppresses α-adrenoceptor-mediated 5-HT release from neuroendocrine epithelial cells (IC50 = 1.3 μM). Facilitates differentiation of neural progenitor cells in vitro.

Technical Data

M.Wt:
222.24
Formula:
C10H14N4O2
Solubility:
Soluble to 75 mM in DMSO and to 50 mM in ethanol
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
28822-58-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Lepski et al (2013) cAMP promotes the differentiation of neural progenitor cells in vitro via modulation of voltage-gated calcium channels. Front.Cell Neurosci. 7 155. PMID: 24065885.

Freitag et al (1998) Phosphodiesterase inhibitors suppress α2-adrenoceptor-mediated 5-hydroxytryptamine release from tracheae of newborn rabbits. Eur.J.Pharmacol. 354 67. PMID: 9726632.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for IBMX include:

Cooke et al (2015) Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptor. Biomed Res Int 172 593. PMID: 24697554.

Elliott et al (2015) Somatostatin and insulin mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP. Am J Physiol Endocrinol Metab 308 E130. PMID: 25406263.

Ghosh et al (2015) The interplay between cyclic AMP, MAPK, and NF-κB pathways in response to proinflammatory signals in microglia. Eneuro 2015 308461. PMID: 25722974.

Merino et al (2015) Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with Isoproterenol. Am J Physiol Lung Cell Mol Physiol 10 e0132884. PMID: 26222156.

Polito et al (2015) Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3). PLoS One 2. PMID: 26465004.

Cuppoletti et al (2013) Methadone but not morphine inhibits lubiprostone-stimulated Cl- currents in T84 intestinal cells and recombinant human ClC-2, but not CFTR Cl- currents. Cell Biochem Biophys 66 53. PMID: 22918821.

Hook et al (2012) Dopaminergic modulation of ganglion-cell photoreceptors in rat. Br J Pharmacol 35 507. PMID: 22304466.

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Keywords: IBMX, supplier, PDE, inhibitors, inhibits, non-selective, Phosphodiesterases, Tocris Bioscience, Phosphodiesterase Inhibitor products

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